hnRNP M1-4 Antibody (3C181): sc-56702

hnRNP M1-4 Antibody (3C181) is a mouse monoclonal IgG1 antibody that detects hnRNP M in mouse, rat, human, bovine, and porcine samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). hnRNP M is a crucial component of the heterogeneous nuclear ribonucleoprotein family, playing a significant role in pre-mRNA splicing and the regulation of gene expression. hnRNP M is primarily located in the nucleus, where hnRNP M participates in the assembly of spliceosomal complexes, which are essential for the accurate processing of pre-mRNA into mature mRNA. Proper functioning of hnRNP M is vital for maintaining cellular homeostasis, as hnRNP M ensures that splicing occurs correctly, thereby influencing the production of functional proteins. Additionally, hnRNP M has been implicated in stress-induced splicing arrest, highlighting hnRNP M′s importance in cellular responses to environmental changes. Anti-hnRNP M antibody (3C181) is an invaluable tool for researchers studying mRNA processing and the intricate regulatory mechanisms that govern gene expression across various species.

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hnRNP M1-4 Antibody (3C181) References:

1. The 72/74-kDa polypeptides of the 70-110 S large heterogeneous nuclear ribonucleoprotein complex (LH-nRNP) represent a discrete subset of the hnRNP M protein family.  |  Kafasla, P., et al. 2000. Biochem J. 350 Pt 2: 495-503. PMID: 10947964
2. Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.  |  Chen, M., et al. 2010. Cancer Res. 70: 8977-80. PMID: 20978194
3. Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.  |  Tsai, PL., et al. 2013. PLoS Pathog. 9: e1003460. PMID: 23825951
4. Selective interactions of hnRNP M isoforms with the TET proteins TAF15 and TLS/FUS.  |  Marko, M., et al. 2014. Mol Biol Rep. 41: 2687-95. PMID: 24474660
5. Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors.  |  Kolisnyk, B., et al. 2016. J Neurosci. 36: 6287-96. PMID: 27277805
6. ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation.  |  Zhu, HE., et al. 2021. J Exp Clin Cancer Res. 40: 64. PMID: 33573689
7. HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability.  |  Prakasam, G., et al. 2022. Virusdisease. 33: 223-235. PMID: 36277414
8. Both RNA-binding domains in heterogenous nuclear ribonucleoprotein A1 contribute toward single-stranded-RNA binding.  |  Shamoo, Y., et al. 1994. Biochemistry. 33: 8272-81. PMID: 7518244
9. The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins.  |  Datar, KV., et al. 1993. Nucleic Acids Res. 21: 439-46. PMID: 8441656
10. Proteins C1 and C2 of heterogeneous nuclear ribonucleoprotein complexes bind RNA in a highly cooperative fashion: support for their contiguous deposition on pre-mRNA during transcription.  |  McAfee, JG., et al. 1996. Biochemistry. 35: 1212-22. PMID: 8573576

The preferred hnRNP M1-4 antibody is hnRNP M1-4 Antibody (1D8): sc-20002.