hnRNP K Antibody (F45 P9 C7): sc-53620

hnRNP K Antibody (F45 P9 C7) is a mouse monoclonal IgG1 antibody that detects hnRNP K in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. hnRNP K plays a crucial role in the regulation of gene expression by participating in mRNA transcription, pre-mRNA processing, and the transport of mature mRNA to the cytoplasm for translation. hnRNP K is primarily localized in the nucleus, where hnRNP K interacts with heterogeneous nuclear RNA (hnRNA) and serves as a key component of the spliceosome, essential for mRNA splicing. hnRNP K contains two K homologous (KH) domains that facilitate protein-protein interactions, allowing recruitment of various molecular partners vital for function. hnRNP K undergoes post-translational modifications, including phosphorylation at several sites, with Ser 302 being a major site for phosphorylation by protein kinase C delta (PKCd). These modifications regulate sequence-specific DNA binding, transcriptional regulation, RNA binding, and nucleocytoplasmic shuttling, highlighting hnRNP K′s importance in maintaining cellular homeostasis and responding to stress signals. anti-hnRNP K antibody (F45 P9 C7) serves as an invaluable tool for researchers studying gene expression and cellular dynamics.

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hnRNP K Antibody (F45 P9 C7) References:

1. Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression.  |  Barboro, P., et al. 2014. Cancer Lett. 352: 152-9. PMID: 25016060
2. hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells.  |  Thompson, PJ., et al. 2015. PLoS Genet. 11: e1004933. PMID: 25611934
3. hnRNP K plays a protective role in TNF-α-induced apoptosis in podocytes.  |  Zhao, S., et al. 2018. Biosci Rep. 38: PMID: 29724888
4. hnRNP K Supports High-Amplitude D Site-Binding Protein mRNA (Dbp mRNA) Oscillation To Sustain Circadian Rhythms.  |  Kwon, PK., et al. 2020. Mol Cell Biol. 40: PMID: 31907279
5. hnRNP K supports the maintenance of RORγ circadian rhythm through ERK signaling.  |  Kwon, PK., et al. 2021. FASEB J. 35: e21507. PMID: 33724572
6. The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies.  |  Malaney, P., et al. 2021. Front Immunol. 12: 634584. PMID: 33912162
7. Crosstalk between hnRNP K and SET in ATRA-induced differentiation in acute promyelocytic leukemia.  |  Padovani, KS., et al. 2021. FEBS Open Bio. 11: 2019-2032. PMID: 34058077
8. Stress-Induced Accumulation of HnRNP K into Stress Granules.  |  Kim, J., et al. 2021. J Cancer Sci Clin Ther. 5: 434-447. PMID: 35340804
9. HnRNP K reduces viral gene expression by targeting cytosine-rich sequences in porcine reproductive and respiratory syndrome virus-2 genome to dampen the viral growth.  |  Jing, H., et al. 2023. Virology. 581: 15-25. PMID: 36842269
10. hnRNP A1, hnRNP A2B1, and hnRNP K are dysregulated in tauopathies, but do not colocalize with tau pathology.  |  Kavanagh, T., et al. 2024. Brain Pathol. e13305. PMID: 39354671

The preferred hnRNP K antibody is hnRNP K Antibody (D-6): sc-28380.