hnRNP E2 Antibody (23-G): sc-101136
- hnRNP E2 Antibody (23-G) is a mouse monoclonal IgG2a κ, cited in 12 publications, provided at 100 µg/ml
- raised against recombinant hnRNP E2 of human origin
- recommended for detection of hnRNP E2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for hnRNP E2 Antibody (23-G) for WB and IHC(P) applications. These reagents are now offered in bundles with hnRNP E2 Antibody (23-G) (see ordering information below).
hnRNP E2 Antibody (23-G) is a mouse monoclonal IgG2a kappa light chain antibody that detects hnRNP E2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-hnRNP E2 antibody (23-G) is available in a non-conjugated form, allowing for versatile experimental use. hnRNP E2, a member of the heterogeneous nuclear ribonucleoprotein family, plays a crucial role in mRNA metabolism, including transcription, pre-mRNA processing, and mature mRNA transport to the cytoplasm for translation. hnRNP E2 is primarily localized in the nucleus, where hnRNP E2 associates with heterogeneous nuclear RNA (hnRNA) produced by RNA polymerase II, and is essential for spliceosomal complex formation. hnRNP E2 stabilizes mRNA, which enhances polioviral mRNA translation, influencing viral replication. hnRNP E2 also interacts with other proteins such as hnRNP M, implicated in pre-mRNA splicing and stress-induced splicing regulation. hnRNP E2′s ability to shuttle between the nucleus and cytoplasm underscores hnRNP E2′s significance in both mRNA stability and translational control, making hnRNP E2 vital for gene expression regulation.
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hnRNP E2 Antibody (23-G) References:
- Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs. | Melcák, I., et al. 2000. Mol Biol Cell. 11: 497-510. PMID: 10679009
- Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. | Kim, JH., et al. 2000. J Mol Biol. 298: 395-405. PMID: 10772858
- Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development. | Mahé, D., et al. 2000. Biochim Biophys Acta. 1492: 414-24. PMID: 11004512
- A nuclear localization domain in the hnRNP A1 protein. | Siomi, H. and Dreyfuss, G. 1995. J Cell Biol. 129: 551-60. PMID: 7730395
- Identification and characterisation of a novel human RNA-binding protein. | Badolato, J., et al. 1995. Gene. 166: 323-7. PMID: 8543184
- The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping. | Gattoni, R., et al. 1996. Nucleic Acids Res. 24: 2535-42. PMID: 8692693
- mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. | Ostareck, DH., et al. 1997. Cell. 89: 597-606. PMID: 9160751
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
hnRNP E2 Antibody (23-G) | sc-101136 | 100 µg/ml | $339.00 | |||
hnRNP E2 Antibody (23-G): m-IgG Fc BP-HRP Bundle | sc-539733 | 100 µg Ab; 10 µg BP | $361.00 | |||
hnRNP E2 Antibody (23-G): m-IgG2a BP-HRP Bundle | sc-546775 | 100 µg Ab; 10 µg BP | $361.00 |