HNF-3β Antibody (B-2): sc-271103
- HNF-3β Antibody (B-2) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 261-370 mapping within an internal region of HNF-3β of human origin
- recommended for detection of HNF-3β of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-271103 X, 200 µg/0.1 ml)
- See HNF-3β (H-4): sc-374376 for HNF-3β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HNF-3β Antibody (B-2). This work is in progress.
HNF-3β Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody raised against amino acids 261-370 mapping within an internal region of HNF-3β of human origin, and exhibits reactivity with mouse, rat, and human proteins in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HNF-3β, also known as FOXA2 (Forkhead Box A2), is a pivotal transcription factor located in the nucleus, where HNF-3β plays a critical role in regulating the expression of genes involved in embryonic development, metabolism, and cell differentiation. Nuclear localization of HNF-3β is essential as HNF-3β functions as a "pioneer" transcription factor, meaning HNF-3β can bind to condensed chromatin and facilitate the access of other transcription factors to DNA, thereby modulating gene expression. HNF-3β is a member of the hepatocyte nuclear factor family, which includes HNF-1 (α and β), HNF-3 (α, β, and γ), HNF-4 (α and γ), and HNF-6, all of which are crucial for the proper functioning of liver, pancreas, and other endoderm-derived tissues. HNF-3β regulates numerous hepatocyte genes in the adult liver and is involved in gastrulation events such as body axis formation. HNF-3β also interacts with HNF-6, indicating a complex network of gene regulation essential for gut endoderm epithelial cell differentiation. Understanding the function and regulation of HNF-3β is important, as HNF-3β has implications in developmental disorders and diseases related to the liver, pancreas, and other organs, making anti-HNF-3β antibody (B-2) a valuable tool for researchers studying these pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNF-3β Antibody (B-2) | sc-271103 | 200 µg/ml | $322.00 | |||
HNF-3β Antibody (B-2) X | sc-271103 X | 200 µg/0.1 ml | $322.00 |