HLA-G Antibody (6D463): sc-71263
- HLA-G Antibody (6D463) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against recombinant HLA-G denatured heavy chain denatured heavy chain of human origin
- recommended for detection of denatured HLA-G heavy chain of human origin by WB, IP, IF and IHC(P)
- See HLA-G (4H84): sc-21799 for HLA-G antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-G Antibody (6D463). This work is in progress.
HLA-G Antibody (6D463) is a mouse monoclonal IgG1 antibody that detects HLA-G in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HLA-G is a non-classical major histocompatibility complex (MHC) class I molecule that plays a crucial role in immune tolerance, particularly during pregnancy, by protecting the fetus from maternal immune rejection. HLA-G (6D463) antibody targets a protein primarily expressed in trophoblast cells of the placenta, where HLA-G helps to modulate the maternal immune response, ensuring a favorable environment for fetal development. The unique expression pattern of HLA-G, along with HLA-G′s ability to inhibit natural killer cell activity and promote regulatory T cell development, underscores its importance in maintaining immune homeostasis. HLA-G′s structure, characterized by a limited polymorphism and the presence of soluble isoforms, further enhances its functional versatility, allowing HLA-G to interact with various receptors and signaling pathways that are vital for immune regulation. Anti-HLA-G antibody (6D463) is an essential tool for researchers studying immune tolerance mechanisms and the role of HLA-G in reproductive immunology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-G Antibody (6D463) References:
- Human leukocyte antigen-G (HLA-G) expression in biliary epithelial cells is associated with allograft acceptance in liver-kidney transplantation. | Créput, C., et al. 2003. J Hepatol. 39: 587-94. PMID: 12971970
- Isoforms of human leukocyte antigen-G and their inhibitory receptors in human kidney allograft acceptance. | Wu, J., et al. 2009. Hum Immunol. 70: 988-94. PMID: 19664670
- The role of HLA-G in immunity and hematopoiesis. | Carosella, ED., et al. 2011. Cell Mol Life Sci. 68: 353-68. PMID: 21116680
- The dual role of HLA-G in cancer. | Rouas-Freiss, N., et al. 2014. J Immunol Res. 2014: 359748. PMID: 24800261
- New Developments in HLA-G in Cardiac Transplantation. | Lazarte, J., et al. 2016. Hum Immunol. 77: 740-5. PMID: 26707934
- Overexpression of Human Leukocyte Antigen-G and Interleukin 10 in acral lentiginous melanoma. | Castillo, MZ., et al. 2017. J Dermatol Sci. 88: 149-152. PMID: 28587737
- Human Leukocyte Antigen-G (HLA-G) Expression in Precancerous and Cancerous Cervical Lesions: Association with Human Papilloma Virus Infection and Host Immune Response. | Fahim, NM., et al. 2018. Egypt J Immunol. 25: 125-134. PMID: 30243004
- HLA-G Expressing Immune Cells in Immune Mediated Diseases. | Contini, P., et al. 2020. Front Immunol. 11: 1613. PMID: 32983083
- Role of the HLA-G immune checkpoint molecule in pregnancy. | Rouas-Freiss, N., et al. 2021. Hum Immunol. 82: 353-361. PMID: 33745758
- Role of HLA-G in tumors and upon COVID-19 infection. | Seliger, B. 2024. Hum Immunol. 85: 110792. PMID: 38555250
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-G Antibody (6D463) | sc-71263 | 100 µg/ml | $322.00 |