HLA-DR/DP Antibody (HL-40): sc-51617

HLA-DR/DP Antibody (HL-40) is a mouse monoclonal IgG2a antibody designed to target the β chain of HLA-DR and HLA-DP proteins, also known as Human Leukocyte Antigen DR and DP or MHC class II DR and DP. These proteins are essential components of the major histocompatibility complex (MHC) class II molecules, which play a pivotal role in the immune system by presenting extracellular antigenic peptides to CD4+ T helper cells, thereby initiating and regulating adaptive immune responses. The structure of HLA-DR and HLA-DP consists of an alpha and a beta chain that form a heterodimer, creating a peptide-binding groove critical for antigen presentation. This structural configuration is vital for the proper binding and display of peptides, facilitating effective communication between antigen-presenting cells and T cells, which is crucial for immune surveillance and response. HLA-DR/DP (HL-40) monoclonal antibody is raised against the Raji cell line, a Burkitt′s lymphoma human cell line, recognizing the β chains of HLA-DR and HLA-DP from human origin across various applications including western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). By accurately targeting the structural components of HLA-DR and HLA-DP, anti-HLA-DR/DP antibody (HL-40) allows researchers to investigate the mechanisms of antigen presentation, immune cell interactions, and the molecular basis of immune-related diseases such as autoimmune disorders and cancers. Available in both conjugated and unconjugated forms, HLA-DR/DP (HL-40) antibody is an indispensable tool for immunologists and researchers aiming to elucidate the complexities of immune regulation and advance immunological research and clinical applications, ultimately contributing to improved patient outcomes and scientific breakthroughs in the field of immunology.

The preferred HLA-DR antibody is HLA-DR Antibody (L243): sc-18875.