HLA-DR Antibody (TAL 1B5): sc-53319

HLA-DR Antibody (TAL 1B5) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize the human HLA-DR protein, a critical component of the Human Leukocyte Antigen (HLA) Class II family, also known as Major Histocompatibility Complex (MHC) Class II DR. HLA-DR protein is a heterodimer composed of alpha and beta chains, each undergoing essential post-translational modifications such as glycosylation, which are crucial for proper protein folding, stability, and cell surface expression. These glycosylation events facilitate HLA-DR′s ability to present exogenous antigens to CD4+ helper T-cells, thereby playing a vital role in initiating and regulating adaptive immune responses. Located on the surface of antigen-presenting cells like B cells, dendritic cells, and macrophages, HLA-DR is integral to the immune system′s ability to distinguish self from non-self, making HLA-DR essential for processes such as pathogen recognition, autoimmune disease development, and transplant compatibility. Anti-HLA-DR antibody (TAL 1B5) effectively detects HLA-DR of mouse, rat, and human origin in various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), providing researchers with versatile tools for studying HLA-DR expression and function. HLA-DR genes, located on chromosome 6p21, exhibit polymorphisms that influence immune responses and disease susceptibility, underscoring the importance of precise HLA-DR detection in both research and clinical diagnostics. HLA-DR monoclonal antibody (TAL 1B5) enables scientists to gain deeper insights into antigen presentation mechanisms, investigate the molecular basis of immune-related diseases, and develop targeted therapeutic strategies, thereby advancing immunological research and clinical applications.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HLA-DR Antibody (TAL 1B5) has 34 citations in a variety of scientific publications.

Primary antibodies like Anti-HLA-DR Antibody (TAL 1B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HLA-DR Antibody (TAL 1B5) Specifications

Alternate Product Name: human leukocyte antigen (HLA) HLA-DR

Product Clone Name: TAL 1B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HLA-DR

Epitope Species: human

Product Reactivity/Detection: HLA-DR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 34 citations in various scientific publications

Available Conjugates/Forms for HLA-DR Antibody (TAL 1B5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred HLA-DR antibody is HLA-DR Antibody (L243): sc-18875.