HLA class I Antibody (YTH862.2): sc-59206

HLA class I Antibody (YTH862.2) is a rat monoclonal IgG2b light chain antibody designed to recognize all classical human leukocyte antigen (HLA) class I molecules, also known as major histocompatibility complex (MHC) class I proteins. These proteins are integral components of the cell membrane, consisting of a heavy α chain and a light β2-microglobulin chain, forming a stable heterodimer that presents endogenous peptide antigens to cytotoxic T lymphocytes. The precise structure of HLA class I molecules is crucial for their role in immune surveillance, enabling the immune system to detect and eliminate infected or malignant cells by presenting peptide fragments derived from intracellular proteins. Anti-HLA class I antibody (YTH862.2) is raised against phytohemagglutinin (PHA)-activated human peripheral blood lymphocytes, demonstrating affinity for native HLA class I proteins in their natural conformation. HLA class I monoclonal antibody (YTH862.2) is recommended for use in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), making this tool essential for researchers studying immune responses, autoimmunity, and transplant biology. Anti-HLA class I antibody (YTH862.2) facilitates the investigation of antigen presentation mechanisms and the interactions between immune cells, thereby contributing to advancements in immunological research and therapeutic development. HLA class I (YTH862.2) antibody′s ability to detect a broad range of classical HLA class I alleles underscores its utility in both basic and clinical settings, providing reliable results across different experimental platforms.

The preferred HLA class I antibody is HLA class I Antibody (HP-1F7): sc-69892.