HLA-B7 Antibody (BB7.1): sc-53304
- HLA-B7 Antibody (BB7.1) is a mouse monoclonal IgG1 κ HLA-B7 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against HLA-B7 of human origin
- HLA-B7 Antibody (BB7.1) is recommended for detection of HLA-B7 of human origin by FCM
- Anti-HLA-B7 Antibody (BB7.1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HLA-B7 Antibody (BB7.1). These reagents are now offered in bundles with HLA-B7 Antibody (BB7.1) (see ordering information below).
HLA-B7 Antibody (BB7.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects HLA-B7 protein of human origin by flow cytometry (FCM). Anti-HLA-B7 antibody (BB7.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HLA-B7 is a crucial component of the major histocompatibility complex (MHC) class I molecules, which are essential for the immune response as they present peptide antigens to T lymphocytes. Specifically, HLA-B7 plays a significant role in the recognition of infected or malignant cells by cytotoxic T cells, thereby facilitating the immune system′s ability to target and eliminate these cells. Expression of HLA-B7 on the surface of nearly all nucleated cells allows for a broad surveillance mechanism, ensuring that the immune system can respond effectively to a variety of pathogens and tumor cells. The polymorphic nature of HLA-B alleles, including HLA-B7, contributes to the diversity of immune responses among individuals, making this protein a critical area of study in immunology and transplantation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-B7 Antibody (BB7.1) References:
- HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story. | Hicklin, DJ., et al. 1999. Mol Med Today. 5: 178-86. PMID: 10203751
- The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. | Morishima, Y., et al. 2002. Blood. 99: 4200-6. PMID: 12010826
- Anchor profiles of HLA-specific peptides: analysis by a novel affinity scoring method and experimental validation. | Desmet, J., et al. 2005. Proteins. 58: 53-69. PMID: 15526297
- The HLA-B7 allele confers susceptibility to breast cancer in Spanish women. | Lavado, R., et al. 2005. Immunol Lett. 101: 223-5. PMID: 16188571
- Optimized vaccination regimen linked to exhaustive screening approaches identifies 2 novel HLA-B7 restricted epitopes within hepatitis C virus NS3 protein. | Martin, P., et al. 2006. Microbes Infect. 8: 2432-41. PMID: 16859951
- Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls. | Gronen, F., et al. 2006. J Neuroimmunol. 180: 185-92. PMID: 17023054
- Immunogenic HLA-B7-restricted peptides of hTRT. | Cortez-Gonzalez, X., et al. 2006. Int Immunol. 18: 1707-18. PMID: 17077179
- Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. | Ploegh, HL., et al. 1981. Cell. 24: 287-99. PMID: 7016338
- Monoclonal antibodies for analysis of the HLA system. | Brodsky, FM., et al. 1979. Immunol Rev. 47: 3-61. PMID: 95015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-B7 Antibody (BB7.1) | sc-53304 | 200 µg/ml | $316.00 | |||
HLA-B7 Antibody (BB7.1): m-IgG Fc BP-HRP Bundle | sc-526792 | 200 µg Ab; 10 µg BP | $354.00 | |||
HLA-B7 Antibody (BB7.1): m-IgG1 BP-HRP Bundle | sc-532165 | 200 µg Ab; 20 µg BP | $354.00 | |||
HLA-B7 Antibody (BB7.1) AC | sc-53304 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HLA-B7 Antibody (BB7.1) HRP | sc-53304 HRP | 200 µg/ml | $316.00 | |||
HLA-B7 Antibody (BB7.1) FITC | sc-53304 FITC | 200 µg/ml | $330.00 | |||
HLA-B7 Antibody (BB7.1) PE | sc-53304 PE | 200 µg/ml | $343.00 | |||
HLA-B7 Antibody (BB7.1) Alexa Fluor® 488 | sc-53304 AF488 | 200 µg/ml | $357.00 | |||
HLA-B7 Antibody (BB7.1) Alexa Fluor® 546 | sc-53304 AF546 | 200 µg/ml | $357.00 | |||
HLA-B7 Antibody (BB7.1) Alexa Fluor® 594 | sc-53304 AF594 | 200 µg/ml | $357.00 | |||
HLA-B7 Antibody (BB7.1) Alexa Fluor® 647 | sc-53304 AF647 | 200 µg/ml | $357.00 | |||
HLA-B7 Antibody (BB7.1) Alexa Fluor® 680 | sc-53304 AF680 | 200 µg/ml | $357.00 | |||
HLA-B7 Antibody (BB7.1) Alexa Fluor® 790 | sc-53304 AF790 | 200 µg/ml | $357.00 |