Histone H2A.X Antibody (980CT1.5.5): sc-517337

Histone H2A.X Antibody (980CT1.5.5) is a mouse monoclonal IgG1 antibody specifically raised against a synthetic peptide corresponding to amino acids 1-30 in the N-terminal region of human Histone H2A.X. Histone H2A.X, also known as H2AX or X variant Histone H2A, is a core component of the nucleosome located in the nucleus, where H2A.X plays a pivotal role in chromatin organization and DNA repair processes. Upon DNA double-stranded breaks, Histone H2A.X becomes rapidly phosphorylated to form γ-H2A.X, signaling the recruitment of DNA repair machinery to maintain genomic stability. The phosphorylated γ-H2A.X initiates the recruitment of repair factors such as Rad50, Rad51, and BRCA1, and forms nuclear foci during class switch recombination in immunoglobulin genes. Nuclear localization of H2A.X is crucial, as H2A.X ensures proper recognition and repair of DNA damage, thereby preventing genomic instability that can lead to diseases like cancer. Anti-Histone H2A.X antibody (980CT1.5.5) reacts with human-origin Histone H2A.X and is suitable for applications in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). By targeting the N-terminal region of H2A.X, Histone H2A.X monoclonal antibody (980CT1.5.5) enables researchers to study the dynamics of chromatin remodeling and cellular responses to DNA damage. Understanding the function and localization of H2A.X is essential for research in DNA repair mechanisms, cancer biology, and the development of therapeutic strategies, making Histone H2A.X (980CT1.5.5) antibody a valuable tool in genomic maintenance studies.

The preferred Histone H2A.X antibody is Histone H2A.X Antibody (938CT5.1.1): sc-517336.