Histone cluster 1 H3D Antibody (6H8): sc-134355

Histone cluster 1 H3D Antibody (6H8) is a mouse monoclonal IgG3 kappa light chain antibody that detects Histone cluster 1 H3D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Histone cluster 1 H3D antibody (6H8) is available as non-conjugated format. Histone cluster 1 H3D (6H8) monoclonal antibody recognizes a protein crucial for chromatin′s structural organization, essential for DNA packaging within the nucleus. By forming nucleosomes, Histone cluster 1 H3D helps regulate gene expression and DNA replication, making this protein vital for cellular function and development. Histone cluster 1 H3D primarily resides in the nucleus, where direct interaction with DNA facilitates genetic material compaction, influencing processes such as transcription and repair. Post-translational modifications, including acetylation and methylation, can alter Histone cluster 1 H3D interaction with DNA and other nuclear proteins, further impacting gene regulation. Histone cluster 1 H3D (HIST1H3D), also known as H3FB, consists of 136 amino acids and is encoded by a gene located in the large histone gene cluster on chromosome 6, highlighting Histone cluster 1 H3D significance in histone biology and epigenetic regulation.

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Histone cluster 1 H3D Antibody (6H8) References:

1. The human and mouse replication-dependent histone genes.  |  Marzluff, WF., et al. 2002. Genomics. 80: 487-98. PMID: 12408966
2. Quantitative proteomic analysis of post-translational modifications of human histones.  |  Beck, HC., et al. 2006. Mol Cell Proteomics. 5: 1314-25. PMID: 16627869
3. Organismal differences in post-translational modifications in histones H3 and H4.  |  Garcia, BA., et al. 2007. J Biol Chem. 282: 7641-55. PMID: 17194708
4. Isolation and characterization of two human H1 histone genes within clusters of core histone genes.  |  Albig, W., et al. 1991. Genomics. 10: 940-8. PMID: 1916825
5. Human histone gene organization: nonregular arrangement within a large cluster.  |  Albig, W., et al. 1997. Genomics. 40: 314-22. PMID: 9119399
6. The human histone gene cluster at the D6S105 locus.  |  Albig, W. and Doenecke, D. 1997. Hum Genet. 101: 284-94. PMID: 9439656
7. Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.  |  El Kharroubi, A., et al. 1998. Mol Cell Biol. 18: 2535-44. PMID: 9566873

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone cluster 1 H3D Antibody (6H8) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone cluster 1 H3D Antibody (6H8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone cluster 1 H3D Antibody (6H8) Specifications

Alternate Product Name: Histone cluster 1 H3D

Product Clone Name: 6H8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-61

Epitope Target: Histone cluster 1 H3D

Epitope Species: human

Product Reactivity/Detection: Histone cluster 1 H3D

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Histone cluster 1 H3D Antibody (6H8): N/A