Histamine H3 Receptor Antibody (D-5): sc-390140

Histamine H3 Receptor Antibody (D-5) is a mouse monoclonal IgM antibody that detects Histamine H3 Receptor of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Histamine H3 Receptor antibody (D-5) is available as the non-conjugated form. Histamine H3 receptor functions as an autoreceptor in the central nervous system (CNS) to modulate histamine synthesis and release. Histamine H3 receptor also regulates various neurotransmitters, maintaining homeostasis in the CNS and other systems, including cardiovascular, gastrointestinal, and respiratory functions. The human Histamine H3 receptor gene is located on chromosome 20 and produces six alternative splice variants, which influence receptor activity and pharmacological responses. These isoforms, differing in transmembrane and intracellular loop structures, indicate that Histamine H3 receptor signaling can be finely tuned through alternative splicing mechanisms. Due to the role in neurotransmitter regulation and responsiveness to various agonists and antagonists, Histamine H3 receptor serves as a promising therapeutic target for conditions such as asthma, epilepsy, and cardiac ischemia.

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Histamine H3 Receptor Antibody (D-5) References:

1. [The roles of histamine H3 receptors in the behavioral disorders and neuropsychopharmacological aspects of its ligands in the brain].  |  Onodera, K. and Miyazaki, S. 1999. Nihon Yakurigaku Zasshi. 114: 89-106. PMID: 10511950
2. Discovery of a novel member of the histamine receptor family.  |  Nguyen, T., et al. 2001. Mol Pharmacol. 59: 427-33. PMID: 11179435
3. Genomic organization and characterization of splice variants of the human histamine H3 receptor.  |  Cogé, F., et al. 2001. Biochem J. 355: 279-88. PMID: 11284713
4. Histamine receptors: an overview.  |  Parsons, ME. 1991. Scand J Gastroenterol Suppl. 180: 46-52. PMID: 1675026
5. Histamine H3 receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion.  |  Iida, T., et al. 2015. Glia. 63: 1213-25. PMID: 25754956
6. Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum.  |  Kononoff Vanhanen, J., et al. 2016. J Pharmacol Exp Ther. 357: 264-72. PMID: 26945087
7. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.  |  Khanfar, MA., et al. 2016. Front Neurosci. 10: 201. PMID: 27303254
8. Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases.  |  Sadek, B., et al. 2016. Behav Brain Res. 312: 415-30. PMID: 27363923
9. Histamine H3 receptor antagonism modulates autism-like hyperactivity but not repetitive behaviors in BTBR T+Itpr3tf/J inbred mice.  |  Molenhuis, RT., et al. 2022. Pharmacol Biochem Behav. 212: 173304. PMID: 34856309
10. Histamine H3 receptor antagonists - Roles in neurological and endocrine diseases and diabetes mellitus.  |  Abdulrazzaq, YM., et al. 2022. Biomed Pharmacother. 150: 112947. PMID: 35447544
11. Histamine inhibits tumor necrosis factor alpha release by mast cells through H2 and H3 receptors.  |  Bissonnette, EY. 1996. Am J Respir Cell Mol Biol. 14: 620-6. PMID: 8652190
12. Histamine H3 receptors--general characterization and their function in the cardiovascular system.  |  Malinowska, B., et al. 1998. J Physiol Pharmacol. 49: 191-211. PMID: 9670104

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histamine H3 Receptor Antibody (D-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Histamine H3 Receptor Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histamine H3 Receptor Antibody (D-5) Specifications

Alternate Product Name: Histamine H3 Receptor

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 301-405

Epitope Target: Histamine H3 Receptor

Epitope Species: human

Product Reactivity/Detection: Histamine H3 Receptor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Histamine H3 Receptor Antibody (D-5): P: Blocking Peptide