Histamine H1 Receptor Antibody (G-11): sc-374621

Histamine H1 Receptor Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Histamine H1 Receptor of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Histamine H1 Receptor (G-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Histamine H1 Receptor plays a crucial role in mediating histamine effects, an important inflammatory mediator influencing physiological processes across central nervous, gastrointestinal, respiratory, and immune systems. This receptor belongs to a larger family of G protein-coupled receptors, including H2, H3, and H4 receptors, each contributing to distinct biological responses. The gene encoding human Histamine H1 Receptor is located on chromosome 3p25 and shows highest expression in placenta, with notable expression in lung, skeletal muscle, kidney, and brain. Understanding Histamine H1 Receptor distribution and function remains vital, as this protein serves as a potential therapeutic target for various conditions, including asthma, allergies, and other inflammatory diseases, highlighting significance in both health and disease management.

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Histamine H1 Receptor Antibody (G-11) References:

1. Discovery of a novel member of the histamine receptor family.  |  Nguyen, T., et al. 2001. Mol Pharmacol. 59: 427-33. PMID: 11179435
2. Genomic organization and characterization of splice variants of the human histamine H3 receptor.  |  Cogé, F., et al. 2001. Biochem J. 355: 279-88. PMID: 11284713
3. Structure and expression of the human histamine H4-receptor gene.  |  Cogé, F., et al. 2001. Biochem Biophys Res Commun. 284: 301-9. PMID: 11394877
4. [Identification and characterization of histamine H4 receptor].  |  Oda, T. and Matsumoto, S. 2001. Nihon Yakurigaku Zasshi. 118: 36-42. PMID: 11496825
5. Histamine receptors: an overview.  |  Parsons, ME. 1991. Scand J Gastroenterol Suppl. 180: 46-52. PMID: 1675026
6. Pharmacokinetic optimisation of histamine H1-receptor antagonist therapy.  |  Simons, FE. and Simons, KJ. 1991. Clin Pharmacokinet. 21: 372-93. PMID: 1685361
7. Nonsedating histamine H1-receptor antagonists.  |  Mann, KV., et al. 1989. Clin Pharm. 8: 331-44. PMID: 2568212
8. Histamine via histamine H1 receptor enhances the muscarinic receptor-induced calcium response to acetylcholine in an enterochromaffin cell model.  |  Pfanzagl, B., et al. 2022. Clin Exp Pharmacol Physiol. 49: 1059-1071. PMID: 35652717
9. Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns.  |  Wang, J., et al. 2023. Front Endocrinol (Lausanne). 14: 1068925. PMID: 36843581
10. Molecular cloning of the human histamine H1 receptor gene.  |  Fukui, H., et al. 1994. Biochem Biophys Res Commun. 201: 894-901. PMID: 8003029
11. Histamine inhibits tumor necrosis factor alpha release by mast cells through H2 and H3 receptors.  |  Bissonnette, EY. 1996. Am J Respir Cell Mol Biol. 14: 620-6. PMID: 8652190
12. Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene.  |  Kobayashi, T., et al. 1996. Genomics. 37: 390-4. PMID: 8938453

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histamine H1 Receptor Antibody (G-11) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Histamine H1 Receptor Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histamine H1 Receptor Antibody (G-11) Specifications

Alternate Product Name: HRH1

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 303-341

Epitope Target: Histamine H1 Receptor

Epitope Species: human

Product Reactivity/Detection: Histamine H1 Receptor

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Histamine H1 Receptor Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin