HIRIP3 Antibody (2415C2a): sc-81096
- HIRIP3 Antibody (2415C2a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of HIRIP3 of human origin
- recommended for detection of HIRIP3 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIRIP3 Antibody (2415C2a). This work is in progress.
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SEE ALSO...
HIRIP3 Antibody (2415C2a) is a mouse monoclonal IgG1 antibody that detects HIRIP3 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. HIRIP3, or HIRA interacting protein 3, is a 556 amino acid protein that plays a crucial role in chromatin function and histone metabolism by directly interacting with the HIRA histone chaperone and exhibiting weak interactions with core histones, specifically Histone H2B and Histone H3. HIRIP3 is heavily phosphorylated, particularly by casein kinase II, and is present throughout the cell cycle, highlighting its importance in cellular processes. Notably, a highly conserved region at the C-terminus of HIRIP3, approximately 60 amino acids in length, contains invariantly charged, polar, and hydrophobic residues, which may be critical for functional interactions. Additionally, two isoforms of HIRIP3 arise from alternative splicing, with isoform 1 predominantly expressed in skeletal muscles and isoform 2 found in the liver and heart, indicating a potential specialization of function in different tissues. The human homologs of HIRA are implicated in developmental disorders such as DiGeorge syndrome, underscoring the significance of HIRIP3 in both normal physiology and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIRIP3 Antibody (2415C2a) | sc-81096 | 100 µg/ml | $339.00 |