HIP2 Antibody (H-6): sc-390339

HIP2 Antibody (H-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects HIP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HIP2 antibody (H-6) is available as the non-conjugated form. HIP2, a crucial component in cellular processes, is primarily located in the cytoplasm and interacts with Huntingtin, a protein associated with Huntington′s disease. This interaction plays a significant role in maintaining membrane-cytoskeletal integrity, essential for proper neuronal function. Disruption of HIP2-Huntingtin interaction can lead to cellular dysfunction and contribute to neurodegenerative disease pathogenesis. While Huntingtin-HIP1 interaction is influenced by polyglutamine length in Huntingtin, HIP2 interaction remains stable regardless of this modification, highlighting potential therapeutic applications. With broad species reactivity and multiple applications, HIP2 (H-6) antibody serves as an invaluable tool for studying molecular mechanisms underlying Huntington′s disease and related disorders.

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HIP2 Antibody (H-6) References:

1. Localization of huntingtin-interacting protein-2 (Hip-2) mRNA in the developing mouse brain.  |  Tanno, Y., et al. 1999. J Chem Neuroanat. 17: 99-107. PMID: 10585161
2. YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes.  |  Wang, Y., et al. 2000. Genomics. 66: 333-6. PMID: 10873389
3. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme.  |  Lee, SJ., et al. 2001. FEBS Lett. 503: 61-4. PMID: 11513855
4. Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.  |  Song, S., et al. 2003. Mol Cell. 12: 553-63. PMID: 14527403
5. [Effects of McAbs HIP2, APT4 and HI117 on the human platelet cytoskeleton].  |  Sun, H. and Li, J. 1992. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 14: 1-5. PMID: 1534277
6. Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells.  |  Wesierska-Gadek, J., et al. 2007. J Cell Biochem. 100: 865-74. PMID: 17203463
7. Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.  |  Ybe, JA., et al. 2007. J Mol Biol. 367: 8-15. PMID: 17257618
8. NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.  |  Metzler, M., et al. 2007. J Neurosci. 27: 2298-308. PMID: 17329427
9. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.  |  Kalchman, MA., et al. 1996. J Biol Chem. 271: 19385-94. PMID: 8702625

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIP2 Antibody (H-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HIP2 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIP2 Antibody (H-6) Specifications

Alternate Product Name: HIP2

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-100

Epitope Target: HIP2

Epitope Species: human

Product Reactivity/Detection: HIP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HIP2 Antibody (H-6): N/A