HIP-55 Antibody (7): sc-135935

HIP-55 Antibody (7) is a mouse monoclonal IgG1 antibody that detects HIP-55 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HIP-55, also known as HPK1-interacting protein of 55 kDa, ABP1, SH3P7, or DBNL, is a 430 amino acid cytoplasmic protein that plays a crucial role in the immune response by acting as an actin-binding adapter protein. HIP-55 is essential for the formation and function of the immunological synapse, where anti-HIP-55 antibody (7) regulates T-cell activation by linking T-cell receptors to the actin cytoskeleton, thereby facilitating gene activation and endocytic processes. The presence of both an ADF-H domain and a SH3 domain in HIP-55 allows interaction with other proteins, such as SHANK2, SHANK3, and PRAM-1, which are vital for maintaining cellular signaling pathways. Additionally, HIP-55 is subject to degradation by caspases during apoptosis, highlighting its importance in both cell survival and immune regulation. With specific reactivity and versatile applications, HIP-55 (7) monoclonal antibody is an invaluable tool for researchers studying T-cell dynamics and actin-related processes in human cells.

The preferred HIP-55 antibody is HIP-55 Antibody (E-11): sc-398498.