HHV-8 K-bZIP Antibody (F33P1): sc-69797

HHV-8 K-bZIP Antibody (F33P1) is a mouse monoclonal IgG1 kappa light chain antibody that detects HHV-8 K-bZIP of HHV-8 origin by western blotting (WB) and immunofluorescence (IF). Anti-HHV-8 K-bZIP antibody (F33P1) is available in a non-conjugated form, specifically designed for researchers studying the mechanisms of HHV-8, also known as Kaposi′s sarcoma-associated herpesvirus. This virus is linked to several serious conditions, including multicentric Castleman′s disease and primary effusion lymphoma, a rare non-Hodgkin lymphoma. HHV-8 K-bZIP, a 237 amino acid homodimeric phosphoprotein, plays a crucial role in regulating viral transcription. HHV-8 K-bZIP functions as a transactivator, utilizing its basic leucine zipper domain to bind to various promoters, thereby initiating the viral replication cycle. HHV-8 K-bZIP is also implicated in the repression of p53-mediated apoptosis, which is vital for viral evasion of host immune responses and enhanced replication. Understanding HHV-8 K-bZIP function is essential for developing therapeutic strategies against HHV-8-related diseases, as this research highlights potential targets for intervention in the viral life cycle and its associated pathologies.

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HHV-8 K-bZIP Antibody (F33P1) References:

1. K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation.  |  Liao, W., et al. 2003. J Virol. 77: 3809-15. PMID: 12610155
2. The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein.  |  Tomita, M., et al. 2004. Oncogene. 23: 8272-81. PMID: 15467747
3. Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure.  |  Al Mehairi, S., et al. 2005. J Virol. 79: 7905-10. PMID: 15919946
4. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification.  |  Izumiya, Y., et al. 2005. J Virol. 79: 9912-25. PMID: 16014952
5. Kaposi's sarcoma-associated herpesvirus K8beta is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8alpha (K-bZIP) to induce p21 and p53 and blocks K8alpha-CDK2 interaction.  |  Yamanegi, K., et al. 2005. J Virol. 79: 14207-21. PMID: 16254356
6. Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP.  |  Izumiya, Y., et al. 2007. J Virol. 81: 1072-82. PMID: 17108053
7. Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.  |  Lefort, S., et al. 2007. J Virol. 81: 10950-60. PMID: 17652396
8. Transcriptional repression of K-Rta by Kaposi's sarcoma-associated herpesvirus K-bZIP is not required for oriLyt-dependent DNA replication.  |  Rossetto, C., et al. 2007. Virology. 369: 340-50. PMID: 17889220
9. Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotype.  |  Kato-Noah, T., et al. 2007. J Virol. 81: 13519-32. PMID: 17913803

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HHV-8 K-bZIP Antibody (F33P1) has 26 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HHV-8 K-bZIP Antibody (F33P1) Specifications

Alternate Product Name: HHV-8 K-bZIP

Product Clone Name: F33P1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: mouse IgG₁ κ kappa light chain

Amino Acids:

Epitope Target: HHV-8 K-bZIP

Epitope Species: HHV-8

Product Reactivity/Detection: sumoylated and non-sumoylated K-bZIP

Species Reactivity/Detection: HHV-8

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for HHV-8 K-bZIP Antibody (F33P1): N/A