HGFL α Antibody (57J13): sc-80040

HGFL α Antibody (57J13) is a mouse monoclonal IgG1 antibody that detects the HGFL alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HGFL alpha antibody (57J13) is available as a non-conjugated format. Hepatocyte growth factor-like protein (HGFL) plays a crucial role in the inflammatory response, acting as a mediator that is essential for the chemotactic response of peritoneal macrophages. This function is particularly important as HGFL helps orchestrate the immune response during tissue injury and infection, facilitating the recruitment of immune cells to sites of inflammation. Unlike hepatocyte growth factor (HGF), which primarily promotes growth and differentiation in epithelial and endothelial cells, HGFL′s role in modulating immune cell behavior highlights its significance in both innate immunity and tissue repair processes. The receptor for HGFL, Ron, is a receptor tyrosine kinase that shares a high degree of homology with the HGF receptor c-Met and is expressed in various epithelial tissues, granulocytes, and monocytes. While HGF does not activate Ron′s tyrosine kinase activity, HGFL induces Ron autophosphorylation in epithelial cells, leading to DNA synthesis, suggesting that Ron serves as the in vivo receptor for HGFL. This unique interaction underscores HGFL′s importance in immune regulation and potential implications in therapeutic strategies targeting inflammatory diseases.

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HGFL α Antibody (57J13) References:

1. Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor.  |  Han, S., et al. 1991. Biochemistry. 30: 9768-80. PMID: 1655021
2. HGF/SF: a potent cytokine for mammary growth, morphogenesis and development.  |  Niranjan, B., et al. 1995. Development. 121: 2897-908. PMID: 7555716
3. Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP).  |  Donate, LE., et al. 1994. Protein Sci. 3: 2378-94. PMID: 7756992
4. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction.  |  Naldini, L., et al. 1995. J Biol Chem. 270: 603-11. PMID: 7822285
5. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.  |  Gaudino, G., et al. 1994. EMBO J. 13: 3524-32. PMID: 8062829
6. Proteolytic activation of hepatocyte growth factor in response to tissue injury.  |  Miyazawa, K., et al. 1994. J Biol Chem. 269: 8966-70. PMID: 8132634
7. Are hepatocyte growth factor-like protein and macrophage stimulating protein the same protein?  |  Bezerra, JA., et al. 1993. Protein Sci. 2: 666-8. PMID: 8518737
8. Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.  |  Tuck, AB., et al. 1996. Am J Pathol. 148: 225-32. PMID: 8546209
9. Functional characterization of domains contained in hepatocyte growth factor-like protein.  |  Waltz, SE., et al. 1997. J Biol Chem. 272: 30526-37. PMID: 9374547

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HGFL α Antibody (57J13) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HGFL α Antibody (57J13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HGFL α Antibody (57J13) Specifications

Alternate Product Name: HGFL α

Product Clone Name: 57J13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HGFL α

Epitope Species: human

Product Reactivity/Detection: HGFL α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HGFL α Antibody (57J13): N/A