hepcidin Antibody (56-Z): sc-100277

Hepcidin Antibody (56-Z) is a mouse monoclonal IgG1 kappa light chain antibody that detects the hepcidin protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-hepcidin antibody (56-Z) is available as a non-conjugated format. Hepcidin, also known as HAMP, HEPC, LEAP1, or HFE2B, is an 84 amino acid secreted protein primarily produced in the liver, where hepcidin plays a vital role in regulating iron homeostasis. Hepcidin (56-Z) antibody recognizes a protein crucial for maintaining iron balance in the body by controlling iron absorption from the intestine and release from macrophages. Hepcidin achieves this by binding to the iron exporter ferroportin, leading to ferroportin internalization and degradation, which effectively reduces iron levels in circulation. Iron regulation is essential not only for preventing iron overload conditions, such as hemochromatosis, but also for ensuring iron availability for critical biological processes, including hemoglobin synthesis and cellular respiration. Additionally, hepcidin exhibits antimicrobial properties, providing a defense mechanism against bacterial infections, which underscores hepcidin′s importance in both iron metabolism and immune response. Defects in the gene encoding hepcidin can lead to hemochromatosis type 2B, a serious condition characterized by excessive iron accumulation and associated complications such as hepatic fibrosis and cardiomyopathy.

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hepcidin Antibody (56-Z) References:

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2. Hepcidin, a urinary antimicrobial peptide synthesized in the liver.  |  Park, CH., et al. 2001. J Biol Chem. 276: 7806-10. PMID: 11113131
3. Chemical synthesis of beta-defensins and LEAP-1/hepcidin.  |  Klüver, E., et al. 2002. J Pept Res. 59: 241-8. PMID: 12010514
4. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.  |  Roetto, A., et al. 2003. Nat Genet. 33: 21-2. PMID: 12469120
5. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis.  |  Merryweather-Clarke, AT., et al. 2003. Hum Mol Genet. 12: 2241-7. PMID: 12915468
6. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.  |  Nemeth, E., et al. 2004. J Clin Invest. 113: 1271-6. PMID: 15124018
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8. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.  |  Nemeth, E., et al. 2004. Science. 306: 2090-3. PMID: 15514116
9. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha.  |  Pinto, JP., et al. 2008. Blood. 111: 5727-33. PMID: 18326822
10. Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis.  |  Li, C., et al. 2025. Hepatol Commun. 9: PMID: 39699302
11. Plasma acute phase proteins as potential predictors of intra-amniotic inflammation and infection in preterm premature rupture of membranes.  |  Cho, HY., et al. 2024. Innate Immun. 17534259241306237. PMID: 39711480
12. A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies.  |  Busti, F., et al. 2025. Haematologica.. PMID: 39744829