Hep B preS2 Antibody (S 26): sc-23944

Hep B preS2 Antibody (S 26) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Hep B preS2 protein of Hep B origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Hep B preS2 monoclonal antibody (S 26) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Hepatitis B virus, a member of the Hepadnavirus family, is notorious for causing liver inflammation, jaundice, and in severe cases, death. The preS2 protein plays a crucial role in the virus′s life cycle, as preS2 is involved in the assembly and secretion of viral particles, which is essential for viral spread and infection of new host cells. Understanding preS2 protein function is vital for developing effective therapeutic strategies and vaccines against Hepatitis B, as preS2 can influence the immune response and the overall pathogenesis of the disease. The three major antigens of the Hepatitis B virus include surface antigen (Hep B sAg, preS1/preS2), e antigen (Hep B eAg), and core antigen (Hep B cAg), with preS2 protein being integral to the formation of the viral envelope. Hep B viral antigens are primarily expressed in the liver, making Hep B preS2 (S 26) antibody an invaluable tool for researchers studying Hepatitis B infection and its associated liver diseases.

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Hep B preS2 Antibody (S 26) References:

1. Targeted destruction of the polymerized human serum albumin binding site within the preS2 region of the HBV surface antigen while retaining full immunogenicity for this epitope.  |  Park, JH., et al. 2003. J Viral Hepat. 10: 70-9. PMID: 12558915
2. Glucose dependent [correction of dependant] negative translational control of the heterologous expression of the preS2 HBV antigen in yeast.  |  Borchani-Chabchoub, I., et al. 2003. Gene. 311: 165-70. PMID: 12853151
3. Presence of anti-preS1, anti-preS2, and anti-HBs antibodies in newborns immunized with Bio-Hep-B vaccine.  |  Madaliński, K., et al. 2004. Med Sci Monit. 10: PI10-7. PMID: 14704645
4. HBV preS2 transactivates FOXP3 expression in malignant hepatocytes.  |  Zhang, X., et al. 2015. Liver Int. 35: 1087-94. PMID: 25047684
5. Identification of neutralizing epitopes in the preS2 domain of the hepatitis B virus.  |  Yato, K., et al. 2023. Virus Res. 323: 199014. PMID: 36511290
6. Rupestonic Acid Derivative YZH-106 Promotes Lysosomal Degradation of HBV L- and M-HBsAg via Direct Interaction with PreS2 Domain.  |  Liu, L., et al. 2024. Viruses. 16: PMID: 39066313
7. Both middle and large envelope proteins can mediate neutralization of hepatitis B virus infectivity by anti-preS2 antibodies: escape by naturally occurring preS2 deletions.  |  Zhang, J., et al. 2024. J Virol. 98: e0192923. PMID: 39078152
8. Quantitative assessment of IgM antibodies towards an immunodominant B-cell epitope within the preS2 domain of HBV in the natural course and during combined prednisone/interferon alpha 2b treatment of chronic hepatitis B virus infection.  |  Fei, GZ., et al. 1995. J Med Virol. 46: 138-43. PMID: 7636501
9. Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.  |  Bichko, V., et al. 1993. Mol Immunol. 30: 221-31. PMID: 7679466
10. Identification of hepatitis B virus core protein regions exposed or internalized at the surface of HBcAg particles by scanning with monoclonal antibodies.  |  Pushko, P., et al. 1994. Virology. 202: 912-20. PMID: 8030252
11. The structure of the variable regions of mouse monoclonal antibodies to hepatitis B virus core antigen.  |  Skrivelis, V., et al. 1993. Scand J Immunol. 37: 637-43. PMID: 8316761
12. Differentiation of core gene products of the hepatitis B virus in infected liver tissue using monoclonal antibodies.  |  Naoumov, NV., et al. 1997. J Med Virol. 53: 127-38. PMID: 9334923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep B preS2 Antibody (S 26) has 11 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep B preS2 Antibody (S 26) Specifications

Alternate Product Name: Hep B preS2

Product Clone Name: S 26

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Hep B preS2

Epitope Species: HBV

Product Reactivity/Detection: an epitope corresponding to amino acids 132-137 of the preS2 region

Species Reactivity/Detection: Hep B

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Hep B preS2 Antibody (S 26): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin