Hep B eAg Antibody (HBe3): sc-51934

Hep B eAg Antibody (HBe3) is a mouse monoclonal IgG2b antibody that detects the e-antigen protein of Hep B origin by enzyme-linked immunosorbent assay (ELISA). The e-antigen plays a crucial role in the Hepatitis B virus life cycle, serving as a marker for viral replication and infection status. Specifically, the e-antigen is a secreted protein produced during the early stages of infection, and its presence in serum indicates active viral replication in hepatocytes. This is particularly important as elevated e-antigen levels are associated with a higher risk of developing severe liver diseases, including hepatocellular carcinoma. The Hep B eAg gene encodes a hydrophobic transmembrane domain, which facilitates protein translocation to the endoplasmic reticulum, where post-translational modifications occur, including signal peptide cleavage. This modification prevents e-antigen assembly into core particles, allowing solubility and detectability in the bloodstream. Anti-Hep B eAg antibody (HBe3) serves as a valuable tool for researchers and clinicians monitoring Hepatitis B infection and assessing the risk of associated liver complications.

The preferred Hep B eAg antibody is Hep B eAg Antibody (AC5): sc-51931.