Heme Oxygenase 2/3 Antibody (B-4): sc-166299

Heme Oxygenase 2/3 Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody engineered against amino acids 1-300 at the N-terminus of mouse Heme Oxygenase 2, ensuring precise targeting and high affinity for both Heme Oxygenase 2 and Heme Oxygenase 3 proteins. Anti-Heme Oxygenase 2/3 antibody (B-4) demonstrates broad species reactivity, effectively recognizing Heme Oxygenase 2 from mouse, rat, and human origins, as well as Heme Oxygenase 3 from rat origin, making it suitable for a wide range of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Heme oxygenases are essential microsomal enzymes that catalyze the degradation of heme into biliverdin, free iron, and carbon monoxide (CO), playing a crucial role in cellular antioxidant defense and heme homeostasis. Heme Oxygenase 2, also called Hmox, HO2, and HO-2, is constitutively expressed in various mammalian tissues, particularly in the brain, where it contributes to the steady production of CO, a gaseous neurotransmitter involved in regulating neuronal signaling pathways analogous to nitric oxide. This CO signaling is vital for maintaining physiological functions such as vascular tone, neurotransmission, and cellular responses to oxidative stress. Heme Oxygenase 3 is present in organs including the spleen, liver, thymus, prostate, heart, kidney, brain, and testis, and contains two heme regulatory motifs that may facilitate heme binding and modulate its enzymatic activity. Heme Oxygenase 2/3 (B-4) antibody is an indispensable tool for researchers studying the intricate roles of heme oxygenase enzymes in disease and health, enabling detailed analysis of their regulatory mechanisms, expression patterns, and functional implications in various biological systems.

The preferred Heme Oxygenase 1/HMOX1 antibody is Heme Oxygenase 1/HMOX1 Antibody (A-3): sc-136960.