Molecular structure of Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1
Application:
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 is a compound able to induce transient mitotic arrest
Molecular Weight:
308.4
Molecular Formula:
C18H16N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 is a cell-permeable thiazolyl benzamide compound that preferentially targets Hec1, disrupts Hec1/Nek2 complex, and destabilizes Nek2 leading to defective localization of Hec1 at kinetochores. Shown to induce transient mitotic arrest, and inhibit the proliferation of several breast cancer cells with a GI50 of 10 - 21 μM; further, reduce tumor outgrowth in a xenograft mouse model (50 mg/kg, i.p.).
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 References
- Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. | Wu, G., et al. 2008. Cancer Res. 68: 8393-9. PMID: 18922912
Inhibitor of:
Hec1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, 10 mg | sc-221711 | 10 mg | $500.00 |