HDGFL1 Antibody (S-18): sc-74088

HDGFL1 Antibody (S-18) is a rat monoclonal IgG2b antibody that detects HDGFL1 of mouse origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-HDGFL1 antibody (S-18) is available as a non-conjugated format. HDGFL1, also known as hepatoma-derived growth factor-like protein 1, PWWP1, or PWWP domain-containing protein 1, consists of 251 amino acids and belongs to the HDGF family. HDGFL1 plays a crucial role in cellular processes, particularly in promoting cell proliferation, which is vital for tissue development and repair. HDGFL1 is predominantly localized in the nucleus and cytoplasm of smooth muscle and endothelial cells during development, highlighting its importance in vascular biology. Expression is notably high in tumor cells, where HDGFL1 acts as a mitogen, stimulating proliferation and contributing to tumor growth. HDGFL1 is involved in organ development and lung remodeling following injury, as HDGFL1 promotes the proliferation of lung epithelial cells. The gene encoding HDGFL1 is located on human chromosome 6 and is conserved across various species, including mouse, rat, chimpanzee, canine, and bovine, underscoring its evolutionary significance.

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HDGFL1 Antibody (S-18) References:

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6. Genome-wide association study of parity in Bangladeshi women.  |  Aschebrook-Kilfoy, B., et al. 2015. PLoS One. 10: e0118488. PMID: 25742292
7. The First Residue of the PWWP Motif Modulates HATH Domain Binding, Stability, and Protein-Protein Interaction.  |  Hung, YL., et al. 2015. Biochemistry. 54: 4063-74. PMID: 26067205