Histone Deacetylase 10 (HDAC10) Antibody (D-9): sc-365270
- Histone Deacetylase 10 (HDAC10) Antibody (D-9) is a mouse monoclonal IgG1 λ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 57-85 within an internal region of HDAC10 of human origin
- recommended for detection of HDAC10 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Histone Deacetylase 10 (HDAC10) Antibody (D-9) for WB applications. This reagent is now offered in a bundle with Histone Deacetylase 10 (HDAC10) Antibody (D-9) (see ordering information below).
HDAC10 Antibody (D-9) is a mouse monoclonal IgG1 lambda light chain antibody engineered to target HDAC10, a pivotal enzyme within the histone deacetylase family that plays a crucial role in chromatin remodeling, transcriptional regulation, and cellular differentiation. Anti-HDAC10 antibody (D-9) recognizes a precise epitope spanning amino acids 57-85 in an internal region of the human HDAC10 protein, also called HD10, ensuring robust specificity and high affinity across mouse, rat, and human species when employed in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. HDAC10 is a member of the class II HDACs, distinguished by its unique structural composition that includes an N-terminal Hda1p-related catalytic domain responsible for its deacetylase activity and a C-terminal leucine-rich domain that facilitates protein-protein interactions and regulates subcellular localization. The structural integrity of HDAC10 is essential for shuttling between the cytoplasm and nucleus in response to cellular signals, thereby modulating gene expression and participating in various cellular processes. The catalytic domain of HDAC10 enables the removal of acetyl groups from histones, leading to chromatin condensation and transcriptional repression, while the leucine-rich domain is critical for interacting with other proteins and maintaining regulatory functions. Understanding the detailed structure of HDAC10 is vital for elucidating its role in epigenetic regulation and potential as a therapeutic target in diseases such as cancer and neurodegeneration. HDAC10 monoclonal antibody (D-9) enables researchers to effectively investigate the structural and functional dynamics of HDAC10, advancing the knowledge of chromatin biology and the development of targeted therapies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Histone Deacetylase 10 Antibody (D-9) | sc-365270 | 200 µg/ml | $316.00 | |||
Histone Deacetylase 10 (HDAC10) Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-542689 | 200 µg Ab; 20 µg BP | $354.00 | |||
Histone Deacetylase 10 (HDAC10) (D-9) Neutralizing Peptide | sc-365270 P | 100 µg/0.5 ml | $68.00 |