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HCAM Antibody (P3H9) is a mouse monoclonal IgG1 antibody that detects HCAM in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HCAM, also known as CD44, LHR, MDU2, MDU3, MIC4, Pgp1, HCELL, MUTCH-I, or ECMR-III, is a 742 amino acid single-pass type I membrane protein that plays a crucial role in hematopoiesis, lymphocyte activation, and tumor metastasis. HCAM functions primarily as a receptor for hyaluronic acid (HA) and interacts with ligands such as osteopontin (OPN), facilitating essential cell-cell and cell-matrix interactions that are vital for cell adhesion and migration. HCAM is characterized by one Link domain and undergoes alternative splicing to produce multiple isoforms, including CD44R, CDw44, CD44S, CD44H (hematopoietic), and CD44E (epithelial). CD44H isoform is expressed at elevated levels in cancer tissues, indicating significant involvement in tumor progression and highlighting HCAM′s importance in cancer biology. Anti-HCAM antibody (P3H9) serves as an invaluable tool for researchers studying cell adhesion and migration dynamics in various biological contexts, particularly in cancer research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD44 Antibody (P3H9) | sc-53505 | 200 µg/ml | $322.00 | |||
CD44 Antibody (P3H9): m-IgGκ BP-HRP Bundle | sc-534154 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD44 Antibody (P3H9): m-IgG1 BP-HRP Bundle | sc-538860 | 200 µg Ab; 20 µg BP | $361.00 |