Molecular structure of HBTU, CAS Number: 94790-37-1
HBTU (CAS 94790-37-1)
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Alternate Names:
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate
Application:
HBTU is a coupling reagent often used in solid phase peptide synthesis
CAS Number:
94790-37-1
Purity:
99%
Molecular Weight:
379.3
Molecular Formula:
C11H16F6N5OP
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HBTU is a commonly used coupling reagent, and can be used in solid phase peptide synthesis. It is reported to convert carboxylic acids into azides efficiently and practically. This process may be used with a wide range of carboxylic acids including N-protected amino acids. It has also been reported to be useful in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids.
HBTU (CAS 94790-37-1) References
- HBTU activation for automated Fmoc solid-phase peptide synthesis. | Fields, CG., et al. 1991. Pept Res. 4: 95-101. PMID: 1815783
- New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU. | Sureshbabu, VV., et al. 2010. Org Biomol Chem. 8: 835-40. PMID: 20135041
- Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. | Hjørringgaard, CU., et al. 2012. J Pept Sci. 18: 199-207. PMID: 22252935
- Amidation reactions from the direct coupling of metal carboxylate salts with amines. | Goodreid, JD., et al. 2014. J Org Chem. 79: 943-54. PMID: 24354665
- HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides. | Mali, SM., et al. 2014. Org Biomol Chem. 12: 8462-72. PMID: 25228027
- Synthesis and bioactivity of nobilamide B. | Jacinto, MP., et al. 2014. RSC Adv. 4: 37609-37612. PMID: 26167276
- Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors. | Kirk, NS., et al. 2016. Bioorg Med Chem Lett. 26: 1813-6. PMID: 26912111
- Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. | McKnelly, KJ., et al. 2020. J Org Chem. 85: 1764-1768. PMID: 31849224
- Fragment synthesis of disulfide-containing peptides. | Dai, Y., et al. 2020. MethodsX. 7: 100945. PMID: 32577409
- Side-product formation during cyclization with HBTU on a solid support. | Story, SC. and Aldrich, JV. 1994. Int J Pept Protein Res. 43: 292-6. PMID: 8005752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HBTU, 100 g | sc-203074 | 100 g | $339.00 | |||
HBTU, 250 g | sc-203074A | 250 g | $676.00 |