HAUSP Antibody (F-2): sc-137001
- HAUSP Antibody (F-2) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 11-210 mapping near the N-terminus of HAUSP of human origin
- recommended for detection of HAUSP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HAUSP Antibody (F-2) for WB and IHC(P) applications. These reagents are now offered in bundles with HAUSP Antibody (F-2) (see ordering information below).
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HAUSP Antibody (F-2) is a mouse monoclonal IgG2a antibody that detects HAUSP (herpesvirus-associated ubiquitin-specific protease, USP7) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). HAUSP plays a critical role in cellular regulation by functioning as a ubiquitin-specific protease that deubiquitinizes key proteins, most notably p53, which is essential for maintaining genomic stability and regulating the cell cycle. HAUSP (F-2) antibody recognizes a protein that stabilizes p53, even in the presence of excess Mdm2, underscoring its importance in tumor suppression and the cellular response to stress. By localizing predominantly in the nucleus, HAUSP interacts with ND10 structures, which are involved in various cellular processes such as stress response, oncogenesis, and viral infection. The gene encoding HAUSP is located on human chromosome band 16p13.2, and its unique distribution pattern within the nucleus, characterized by a micropunctate arrangement with larger discrete foci, facilitates its interaction with other nuclear proteins, including PML, further emphasizing its role in cellular homeostasis and response mechanisms.
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HAUSP Antibody (F-2) References:
- A dynamic role of HAUSP in the p53-Mdm2 pathway. | Li, M., et al. 2004. Mol Cell. 13: 879-86. PMID: 15053880
- ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. | Meulmeester, E., et al. 2005. Cell Cycle. 4: 1166-70. PMID: 16082221
- Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. | Huang, Z., et al. 2011. Nat Cell Biol. 13: 142-52. PMID: 21258371
- Roles of HAUSP-mediated p53 regulation in central nervous system development. | Kon, N., et al. 2011. Cell Death Differ. 18: 1366-75. PMID: 21350561
- Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. | Lee, HR., et al. 2011. Nat Struct Mol Biol. 18: 1336-44. PMID: 22056774
- HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator. | Bhattacharya, S. and Ghosh, MK. 2014. FEBS J. 281: 3061-78. PMID: 24823443
- HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. | Tavana, O., et al. 2016. Nat Med. 22: 1180-1186. PMID: 27618649
- HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner. | Zhang, R., et al. 2020. J Mol Cell Biol. 12: 99-112. PMID: 31647545
- HAUSP promoted the growth of glioma cells in vitro and in vivo via stabilizing NANOG. | Cheng, CD., et al. 2020. Pathol Res Pract. 216: 152883. PMID: 32088087
- HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response. | Das, S., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118835. PMID: 32860838
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HAUSP Antibody (F-2) | sc-137001 | 200 µg/ml | $316.00 | |||
HAUSP Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-537386 | 200 µg Ab; 10 µg BP | $354.00 | |||
HAUSP Antibody (F-2): m-IgGκ BP-HRP Bundle | sc-534637 | 200 µg Ab; 40 µg BP | $354.00 | |||
HAUSP Antibody (F-2): m-IgG2a BP-HRP Bundle | sc-548000 | 200 µg Ab; 10 µg BP | $354.00 |