HAPLN2 Antibody (F-7): sc-376797
- HAPLN2 Antibody (F-7) is a mouse monoclonal IgG1 κ HAPLN2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 26-101 mapping within an internal region of HAPLN2 of human origin
- HAPLN2 Antibody (F-7) is recommended for detection of HAPLN2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-HAPLN2 Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HAPLN2 Antibody (F-7) for WB applications. These reagents are now offered in bundles with HAPLN2 Antibody (F-7) (see ordering information below).
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HAPLN2 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects HAPLN2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HAPLN2 antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HAPLN2, also known as hyaluronan and proteoglycan link protein 2 or brain link protein 1, consists of 340 amino acids and is encoded by the human gene HAPLN2. HAPLN2 plays a crucial role in the central nervous system by mediating the binding of versican V2 to hyaluronic acid, contributing to the formation of the hyaluronan-associated matrix. This matrix is essential for neuronal conduction and structural stabilization, supporting the integrity of perineuronal nets that surround neurons. HAPLN2 is predominantly located in several nuclei throughout the midbrain and hindbrain, where HAPLN2 presence in a perineuronal net pattern underscores HAPLN2′s importance in maintaining the extracellular environment necessary for optimal neuronal function. HAPLN2′s ability to interact with other extracellular matrix components highlights HAPLN2′s potential role in neuroprotection and the modulation of synaptic activity, making HAPLN2 a significant target for research in neurobiology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HAPLN2 Antibody (F-7) References:
- The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. | Hirakawa, S., et al. 2000. Biochem Biophys Res Commun. 276: 982-9. PMID: 11027579
- Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. | Oohashi, T., et al. 2002. Mol Cell Neurosci. 19: 43-57. PMID: 11817897
- Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. | Nomoto, H., et al. 2002. Acta Med Okayama. 56: 25-9. PMID: 11873941
- A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. | Spicer, AP., et al. 2003. J Biol Chem. 278: 21083-91. PMID: 12663660
- Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets. | Bekku, Y., et al. 2003. Mol Cell Neurosci. 24: 148-59. PMID: 14550776
- [Bral1, Bral2: the novel brain specific-hyaluronan and protoglycan link protein genes]. | Oohashi, T., et al. 2004. Tanpakushitsu Kakusan Koso. 49: 2354-61. PMID: 15552986
- Production of hyaluronan-dependent pericellular matrix by embryonic rat glial cells. | Deyst, KA. and Toole, BP. 1995. Brain Res Dev Brain Res. 88: 122-5. PMID: 7493403
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HAPLN2 Antibody (F-7) | sc-376797 | 200 µg/ml | $322.00 | |||
HAPLN2 Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-523097 | 200 µg Ab, 40 µg BP | $361.00 | |||
HAPLN2 Antibody (F-7): m-IgG1 BP-HRP Bundle | sc-533552 | 200 µg Ab; 20 µg BP | $361.00 | |||
HAPLN2 Antibody (F-7) AC | sc-376797 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HAPLN2 Antibody (F-7) HRP | sc-376797 HRP | 200 µg/ml | $322.00 | |||
HAPLN2 Antibody (F-7) FITC | sc-376797 FITC | 200 µg/ml | $336.00 | |||
HAPLN2 Antibody (F-7) PE | sc-376797 PE | 200 µg/ml | $349.00 | |||
HAPLN2 Antibody (F-7) Alexa Fluor® 488 | sc-376797 AF488 | 200 µg/ml | $364.00 | |||
HAPLN2 Antibody (F-7) Alexa Fluor® 546 | sc-376797 AF546 | 200 µg/ml | $364.00 | |||
HAPLN2 Antibody (F-7) Alexa Fluor® 594 | sc-376797 AF594 | 200 µg/ml | $364.00 | |||
HAPLN2 Antibody (F-7) Alexa Fluor® 647 | sc-376797 AF647 | 200 µg/ml | $364.00 | |||
HAPLN2 Antibody (F-7) Alexa Fluor® 680 | sc-376797 AF680 | 200 µg/ml | $364.00 | |||
HAPLN2 Antibody (F-7) Alexa Fluor® 790 | sc-376797 AF790 | 200 µg/ml | $364.00 |