HAH1 Antibody (D-9): sc-398742
- HAH1 Antibody (D-9) is a mouse monoclonal IgG2a κ HAH1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-68 representing full length HAH1 of human origin
- HAH1 Antibody (D-9) is recommended for detection of HAH1 of human origin by WB, IP, IF and ELISA
- Anti-HAH1 Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for HAH1 Antibody (D-9) for WB applications. These reagents are now offered in bundles with HAH1 Antibody (D-9) (see ordering information below).
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SEE ALSO...
HAH1 Antibody (D-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects HAH1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HAH1 antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HAH1, also known as ATOX1, plays a crucial role in cellular copper transport and homeostasis, functioning as a copper chaperone that delivers copper ions to specific P-type ATPases located in the Golgi apparatus, such as ATP7A and ATP7B in humans. This process is vital for maintaining copper balance within cells, as copper is an essential trace element involved in numerous biological processes, including enzymatic reactions and antioxidant defense. HAH1′s ability to bind and transfer copper to ATP7B, particularly through interaction with domains 2 and 4, underscores HAH1′s importance in cellular antioxidant defense mechanisms. The efficient delivery of copper by HAH1 is essential for proper functioning of copper-dependent enzymes, and any disruption in this process can lead to copper-related disorders, highlighting HAH1′s significance in maintaining cellular health and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HAH1 Antibody (D-9) References:
- Intracellular copper routing: the role of copper chaperones. | Harrison, MD., et al. 2000. Trends Biochem Sci. 25: 29-32. PMID: 10637610
- Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene. | Boultwood, J., et al. 2000. Hum Genet. 106: 127-9. PMID: 10982193
- Copper-dependent protein-protein interactions studied by yeast two-hybrid analysis. | van Dongen, EM., et al. 2004. Biochem Biophys Res Commun. 323: 789-95. PMID: 15381069
- Solution structure of the apo and copper(I)-loaded human metallochaperone HAH1. | Anastassopoulou, I., et al. 2004. Biochemistry. 43: 13046-53. PMID: 15476398
- Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. | Klomp, LW., et al. 1997. J Biol Chem. 272: 9221-6. PMID: 9083055
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HAH1 Antibody (D-9) | sc-398742 | 200 µg/ml | $322.00 | |||
HAH1 Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-526323 | 200 µg Ab; 10 µg BP | $361.00 | |||
HAH1 Antibody (D-9): m-IgG2a BP-HRP Bundle | sc-546584 | 200 µg Ab; 10 µg BP | $361.00 | |||
HAH1 Antibody (D-9) AC | sc-398742 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HAH1 Antibody (D-9) HRP | sc-398742 HRP | 200 µg/ml | $322.00 | |||
HAH1 Antibody (D-9) FITC | sc-398742 FITC | 200 µg/ml | $336.00 | |||
HAH1 Antibody (D-9) PE | sc-398742 PE | 200 µg/ml | $349.00 | |||
HAH1 Antibody (D-9) Alexa Fluor® 488 | sc-398742 AF488 | 200 µg/ml | $364.00 | |||
HAH1 Antibody (D-9) Alexa Fluor® 546 | sc-398742 AF546 | 200 µg/ml | $364.00 | |||
HAH1 Antibody (D-9) Alexa Fluor® 594 | sc-398742 AF594 | 200 µg/ml | $364.00 | |||
HAH1 Antibody (D-9) Alexa Fluor® 647 | sc-398742 AF647 | 200 µg/ml | $364.00 | |||
HAH1 Antibody (D-9) Alexa Fluor® 680 | sc-398742 AF680 | 200 µg/ml | $364.00 | |||
HAH1 Antibody (D-9) Alexa Fluor® 790 | sc-398742 AF790 | 200 µg/ml | $364.00 |