H2-I/Adβ Antibody (34-5-3): sc-52538

H2-I/Adβ Antibody (34-5-3) is a mouse monoclonal IgG2a antibody that detects H2-I/Ad beta protein of mouse origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-H2-I/Ad beta antibody (34-5-3) is available as the non-conjugated form. H2-I/Ad beta protein plays a crucial role in the immune system as a component of the major histocompatibility complex (MHC) class II molecules, which are essential for the adaptive immune response. These molecules are responsible for presenting processed foreign peptides to CD4+ T helper cells, thereby initiating a cascade of immune responses that help the body fight infections. Proper functioning of MHC class II molecules is vital for the activation of T lymphocytes, which are key players in orchestrating the immune response. Any dysfunction or alteration in H2-I/Ad beta expression can lead to impaired immune responses and has been associated with various autoimmune diseases. H2-I/Ad beta monoclonal antibody (34-5-3) is an invaluable tool for researchers studying the mechanisms of immune activation and the role of MHC molecules in health and disease.

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H2-I/Adβ Antibody (34-5-3) References:

1. Signal transduction by the major histocompatibility complex class I molecule.  |  Pedersen, AE., et al. 1999. APMIS. 107: 887-95. PMID: 10549585
2. Presentation of antigens by MHC class II molecules: getting the most out of them.  |  Villadangos, JA. 2001. Mol Immunol. 38: 329-46. PMID: 11684289
3. Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior.  |  Chaves, FA., et al. 2006. Biochemistry. 45: 6426-33. PMID: 16700553
4. Influence of major histocompatibility complex class I, class II and TLA genes on tumor rejection.  |  Ostrand-Rosenberg, S., et al. 1991. Semin Cancer Biol. 2: 311-9. PMID: 1773047
5. The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.  |  Landias, D., et al. 1986. J Immunol. 137: 3002-5. PMID: 3463623
6. Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.  |  Allen, H., et al. 1986. Proc Natl Acad Sci U S A. 83: 7447-51. PMID: 3532114
7. Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon.  |  Larhammar, D., et al. 1983. Cell. 34: 179-88. PMID: 6411350
8. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.  |  Ozato, K. and Sachs, DH. 1981. J Immunol. 126: 317-21. PMID: 6935293
9. Structure and function of H-2 T (Tla) region class I MHC molecules.  |  Teitell, M., et al. 1994. Crit Rev Immunol. 14: 1-27. PMID: 7741975
10. Assembly, transport, and function of MHC class II molecules.  |  Cresswell, P. 1994. Annu Rev Immunol. 12: 259-93. PMID: 8011283
11. Antigen presentation by major histocompatibility complex class I-B molecules.  |  Shawar, SM., et al. 1994. Annu Rev Immunol. 12: 839-80. PMID: 8011299
12. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.  |  Muhlethaler-Mottet, A., et al. 1997. EMBO J. 16: 2851-60. PMID: 9184229

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-H2-I/Adβ Antibody (34-5-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-H2-I/Adβ Antibody (34-5-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

H2-I/Adβ Antibody (34-5-3) Specifications

Alternate Product Name: H2-I/Adβ

Product Clone Name: 34-5-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: H2-I/Adβ

Epitope Species: mouse

Product Reactivity/Detection: H2-I/Adβ

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for H2-I/Adβ Antibody (34-5-3): N/A

The preferred H2-I-A/I-E antibody is H2-I-A/I-E Antibody (M5/114): sc-23940.