H2-I-A/I-E Antibody (M5/114.15.2): sc-81730
- H2-I-A/I-E Antibody (M5/114.15.2) is a rat monoclonal IgG2b, cited in 1 publications, provided at 200 µg/ml
- raised against activated C57BL/6 mouse spleen cells
- recommended for detection of I-Ab, I-Ad, I-Aq, I-Ed and I-Ek MHC class II alloantigens of mouse origin by IF and FCM; non cross-reactive with I-Af, I-Ak or I-As; detects a polymorphic determinant present on B cells, monocytes, macrophages, dendritic cells and activated T lymphocytes from mice carrying the H-2b, H-2d, H-2q, H-2p, H-2r and H-2u haplotypes, but not mice carrying the H-2s or H-2f
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-I-A/I-E Antibody (M5/114.15.2). This work is in progress.
H2-I-A/I-E Antibody (M5/114.15.2) is a rat monoclonal IgG2b antibody that detects H2-I-A/I-E in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. H2-I-A/I-E molecules, which are part of the major histocompatibility complex (MHC) class II, play a crucial role in the immune system by presenting processed foreign antigens to CD4+ T lymphocytes, thereby initiating an adaptive immune response. The structure of H2-I-A/I-E consists of two polypeptide chains, an alpha and a beta chain, that form a heterodimer. This unique structure allows for the binding of a diverse array of peptide fragments, which is essential for the effective activation of T cells. The ability of H2-I-A/I-E to present a variety of peptides is vital for the immune system′s ability to recognize and respond to a wide range of pathogens, making H2-I-A/I-E a key player in immune surveillance and response. Anti-H2-I-A/I-E antibody (M5/114.15.2) specifically reacts with the I-A and I-E subregion-encoded glycoproteins, including I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek, while showing no reactivity with I-Af, I-Ak, or I-As, thus providing a valuable tool for studying immune responses in various mouse haplotypes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-I-A/I-E Antibody (M5/114.15.2) | sc-81730 | 200 µg/ml | $322.00 | |||
H2-I-A/I-E Antibody (M5/114.15.2) FITC | sc-81730 FITC | 200 µg/ml | $336.00 | |||
H2-I-A/I-E Antibody (M5/114.15.2) PE | sc-81730 PE | 200 µg/ml | $349.00 |