H2-Db Antibody (5K48): sc-71198
- H2-Db Antibody (5K48) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against C3H.SW splenocytes of mouse origin
- recommended for detection of α3 domain of H2-Db class I MHC antigen of mouse origin by IF and FCM; also recommended for detection of the a3 domain of H2-Ld, H2-Dq and H2-Lq; non cross-reactive with H2-Kd or H2-Dd
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for Complement-dependent cytotoxicity assay, sc-71198 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-Db Antibody (5K48). This work is in progress.
H2-Db Antibody (5K48) is a mouse monoclonal IgG2a antibody that detects H2-Db in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. H2-Db is a crucial component of the major histocompatibility complex (MHC) Class I molecules, which play a vital role in the immune response by presenting endogenously synthesized peptides to CD8+ T lymphocytes, primarily cytotoxic T cells. H2-Db (5K48) antibody enables researchers to study proper functioning of H2-Db, which is essential for the activation and regulation of these T cells, as H2-Db influences their ability to recognize and eliminate infected or malignant cells. H2-Db is expressed on most nucleated cells, with expression levels varying by cell type, which is significant for the immune system′s ability to distinguish between self and non-self. H2-Db expression on thymic epithelial cells is particularly important, as H2-Db regulates the positive and negative selection processes of CD8+ T cells during their development, ensuring a functional and self-tolerant T cell repertoire. H2-Db can modulate the activity of natural killer (NK) cells, either inhibiting or activating their cytotoxic functions, thereby playing a critical role in the innate immune response. With insights into immune cell interactions and responses, anti-H2-Db antibody (5K48) serves as an invaluable tool for researchers studying immunology and related fields.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-Db Antibody (5K48) | sc-71198 | 100 µg/ml | $322.00 | |||
H2-Db Antibody (5K48) FITC | sc-71198 FITC | 100 tests in 2 ml | $336.00 | |||
H2-Db Antibody (5K48) L | sc-71198 L | 100 µg/0.1 ml | $322.00 | |||
H2-Db Antibody (5K48) PE | sc-71198 PE | 100 tests in 2 ml | $349.00 |