H2-Db Antibody (5K45): sc-71199
- H2-Db Antibody (5K45) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against C3H.SW splenocytes of mouse origin
- recommended for detection of α3 domain of H2-Db class I MHC antigen of mouse origin by IF and FCM; may cross-react with the α3 domain of H2-Ld and with H2-Dq and H2-Lq; non cross-reactive with H2-Kd or H2-Dd
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-Db Antibody (5K45). This work is in progress.
H2-Db Antibody (5K45) is a mouse monoclonal IgG2a antibody that detects H2-Db in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. H2-Db is a crucial component of the major histocompatibility complex (MHC) Class I molecules, which play a vital role in the immune response by presenting endogenously synthesized peptides to CD8+ T lymphocytes, primarily cytotoxic T cells. H2-Db (5K45) antibody enables researchers to study proper functioning of H2-Db, which is essential for the activation and regulation of these T cells, as H2-Db influences their ability to recognize and eliminate infected or malignant cells. H2-Db is expressed on most nucleated cells, with expression levels varying by cell type, which is significant for the immune system′s ability to distinguish between self and non-self. H2-Db expression on thymic epithelial cells is particularly important, as H2-Db regulates the positive and negative selection processes of CD8+ T cells during their development, ensuring that a functional and self-tolerant T cell repertoire is established. H2-Db can modulate the activity of natural killer (NK) cells, either inhibiting or activating their cytotoxic functions, thereby influencing the overall immune response. With this critical role in immune regulation and T cell development, anti-H2-Db antibody (5K45) serves as an invaluable tool for researchers studying immune mechanisms and T cell biology in mouse models.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-Db Antibody (5K45) | sc-71199 | 100 µg/ml | $322.00 | |||
H2-Db Antibody (5K45) FITC | sc-71199 FITC | 100 tests in 2 ml | $336.00 | |||
H2-Db Antibody (5K45) PE | sc-71199 PE | 100 tests in 2 ml | $349.00 |