GW441756 hydrochloride (CAS 504433-24-3 (free base))
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GW441756 hydrochloride is used in the field of neuroscience and neurobiology research due to its action as a potent and selective inhibitor of the tropomyosin receptor kinase (Trk), specifically TrkA. Studies involving GW441756 hydrochloride aim to understand the signaling pathways involved in neuronal survival, development, and function, which are mediated by Trk receptors. This compound is also employed in research looking to elucidate the molecular mechanisms underlying neurodegenerative conditions. In cellular models, GW441756 hydrochloride is utilized to probe the role of TrkA in mediating responses to nerve growth factor (NGF). Additionally, it is of interest in the study of pain perception, as TrkA inhibition has implications in the modulation of pain pathways.
GW441756 hydrochloride (CAS 504433-24-3 (free base)) References
- Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. | Wood, ER., et al. 2004. Bioorg Med Chem Lett. 14: 953-7. PMID: 15013000
- Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. | Terada, K., et al. 2018. PLoS One. 13: e0209250. PMID: 30557385
- Asiaticoside but not its aglycone exhibits neuritogenicity through TrkA receptor signaling: a bridge between ERK1/2-CREB and Akt-GSK3β/RhoA. | Nalinratana, N., et al. 2019. Neuroreport. 30: 1261-1270. PMID: 31651704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW441756 hydrochloride, 5 mg | sc-215121 | 5 mg | $140.00 |