GTBP Antibody (F-1): sc-271979
- GTBP Antibody (F-1) is a mouse monoclonal IgG1 λ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 63-97 near the N-terminus of GTBP of human origin
- recommended for detection of GTBP of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GTBP Antibody (F-1) for WB applications. These reagents are now offered in bundles with GTBP Antibody (F-1) (see ordering information below).
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GTBP Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects GTBP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GTBP, also known as MSH6, plays a crucial role in the DNA mismatch repair process, which is essential for maintaining genomic stability and preventing mutations that can lead to cancer, particularly hereditary nonpolyposis colorectal cancer (HNPCC). GTBP is primarily located in the nucleus, where GTBP forms a heterodimer with MSH2 to recognize and bind to G/T mismatches in DNA, thereby facilitating the repair of erroneous DNA sequences. Proper functioning of GTBP is vital, as defects in GTBP can result in microsatellite instability, a hallmark of various cancers. GTBP (F-1) antibody enables researchers to gain insights into the mechanisms of DNA repair and the implications of GTBP dysfunction in cancer biology, making GTBP (F-1) monoclonal antibody an invaluable tool for studies focused on genetic stability and tumorigenesis.
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GTBP Antibody (F-1) References:
- hMSH2 and GTBP expression in advanced stage epithelial ovarian cancer. | Ercoli, A., et al. 1999. Br J Cancer. 80: 1665-71. PMID: 10408416
- Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. | Edelbrock, MA., et al. 2013. Mutat Res. 743-744: 53-66. PMID: 23391514
- GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. | Palombo, F., et al. 1995. Science. 268: 1912-4. PMID: 7604265
- MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. | Iaccarino, I., et al. 1996. Curr Biol. 6: 484-6. PMID: 8723353
- cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene. | Corradi, A., et al. 1996. Genomics. 36: 288-95. PMID: 8812455
- Molecular cloning of the N-terminus of GTBP. | Nicolaides, NC., et al. 1996. Genomics. 31: 395-7. PMID: 8838326
- Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells increases G/T mismatch-binding protein expression. | Donohue, PJ., et al. 1996. Biochem J. 319 (Pt 1): 9-12. PMID: 8870641
- Alternative splicing of GTBP in normal human tissues. | Shiwaku, HO., et al. 1997. DNA Res. 4: 359-62. PMID: 9455487
- Proteins that interact with facilitative glucose transporters: implication for function. | Jung, CY. 1998. Exp Physiol. 83: 267-73. PMID: 9568488
- Mononucleotide repeat instability is infrequent in neuroblastoma. | Hogarty, MD., et al. 1998. Cancer Genet Cytogenet. 106: 140-3. PMID: 9797779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GTBP Antibody (F-1) | sc-271979 | 200 µg/ml | $322.00 | |||
GTBP Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-540274 | 200 µg Ab; 10 µg BP | $361.00 | |||
GTBP Antibody (F-1): m-IgG1 BP-HRP Bundle | sc-542017 | 200 µg Ab; 20 µg BP | $361.00 | |||
GTBP (F-1) Neutralizing Peptide | sc-271979 P | 100 µg/0.5 ml | $69.00 |