GTBP Inhibitors
GTBP inhibitors belong to a unique chemical class within the realm of molecular compounds that have garnered significant attention in recent years. These compounds are characterized by their ability to interact with and modulate the activity of GTBP, which stands for "G-quadruplex binding protein." GTBP is a vital protein involved in the recognition and binding of G-quadruplex DNA structures. G-quadruplexes are secondary structures of DNA that form when guanine-rich regions of the DNA molecule fold into a four-stranded helical conformation, involving Hoogsteen hydrogen bonding. These structures are abundant in the human genome, particularly in regulatory regions such as promoters and telomeres.
GTBP inhibitors are designed to interfere with the interaction between GTBP and G-quadruplexes, ultimately influencing the regulation of gene expression. They achieve this by binding to GTBP or the G-quadruplex DNA, disrupting the normal functioning of this protein-DNA interaction. The unique feature of GTBP inhibitors lies in their potential to modulate various cellular processes by altering the expression of specific genes
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor that impacts GTBP indirectly by preventing DNA repair, as GTBP is involved in DNA damage response. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $182.00 $275.00 $726.00 | 3 | |
PARP inhibitor that, like Olaparib, indirectly affects GTBP function by inhibiting DNA repair processes. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Another PARP inhibitor that can impact GTBP by hindering DNA repair mechanisms. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
PARP inhibitor that indirectly influences GTBP's role in the DNA damage response pathway. | ||||||
Niraparib | 1038915-60-4 | sc-507492 | 10 mg | $150.00 | ||
PARP inhibitor that can affect GTBP indirectly through the inhibition of DNA repair. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
A chemical that can increase reactive oxygen species, thereby potentially increasing DNA damage and indirectly challenging GTBP's DNA repair function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
ATM and ATR kinase inhibitor that can indirectly affect GTBP by impairing the cell's response to DNA damage. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
ATM inhibitor that can affect GTBP indirectly by disrupting the cellular response to DNA damage. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
Improved analog of KU-55933 which also acts as an ATM inhibitor and can affect GTBP indirectly. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
DNA-PKcs inhibitor that can indirectly impact GTBP by affecting the NHEJ pathway of DNA repair. | ||||||