GSTO1/2 Antibody (D-12): sc-166040

GSTO1/2 Antibody (D-12) is a mouse monoclonal IgG2a antibody that detects GSTO1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GSTO1, also known as glutathione S-transferase omega 1 or p28, is a 241 amino acid protein that plays a crucial role in cellular detoxification processes by catalyzing the conjugation of glutathione to organic compounds, forming thioethers that facilitate the metabolism and elimination of xenobiotics and carcinogens. GSTO1 is predominantly localized in the cytoplasm and exists as a homodimer, featuring both N-terminal and C-terminal GST domains essential for enzymatic activity. Polymorphisms in the GSTO1 gene have been linked to susceptibility to various diseases, including childhood acute lymphoblastic leukemia, Parkinson′s disease, and Alzheimer′s disease, highlighting GSTO1′s potential role in disease mechanisms. GSTO2, a related protein, shares functional similarities with GSTO1 and is expressed in various tissues, further underscoring the significance of the glutathione S-transferase family in maintaining cellular health and responding to oxidative stress. GSTO1/2 (D-12) antibody serves as an invaluable tool for researchers investigating these proteins in health and disease.

The preferred GSTO1/2 antibody is GSTO1/2 Antibody (H-12): sc-166121.