GSTA1 Antibody (286CT8.1.5): sc-517334
- GSTA1 Antibody (286CT8.1.5) is a mouse monoclonal IgM provided at 100 µg/ml
- raised against a recombinant protein corresponding to GSTA1 of human origin
- recommended for detection of GSTA1 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GSTA1 Antibody (286CT8.1.5). This work is in progress.
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GSTA1 Antibody (286CT8.1.5) is a mouse monoclonal IgM antibody that detects GSTA1 in human samples through western blotting (WB). GSTA1, a member of the glutathione S-transferase (GST) family, plays a crucial role in the detoxification of xenobiotics, thereby protecting cells from toxicant-induced damage. GSTA1 is predominantly expressed in the liver, lung, and kidney tissues, where GSTA1 helps to mitigate the effects of harmful substances. Notably, GSTA1 is involved in the conjugation of aflatoxin B1 epoxide, highlighting GSTA1′s significance in cellular defense against both chemical and oxidative stress. GSTA1′s structure includes a C-terminal domain that may contribute to the hydrophobic substrate-binding site, although this domain is not directly involved in glutathione binding and is not essential for catalytic activity. Understanding the function and localization of GSTA1 is vital, as GSTA1′s activity can influence cellular responses to environmental toxins and contribute to the overall detoxification processes within the body. Anti-GSTA1 antibody (286CT8.1.5) is an invaluable tool for researchers studying the mechanisms of detoxification and the role of GSTs in cellular protection.
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GSTA1 Antibody (286CT8.1.5) References:
- Human GSTA1-1 reduces c-Jun N-terminal kinase signalling and apoptosis in Caco-2 cells. | Romero, L., et al. 2006. Biochem J. 400: 135-41. PMID: 16836488
- Low levels of GSTA1 expression are required for Caco-2 cell proliferation. | Adnan, H., et al. 2012. PLoS One. 7: e51739. PMID: 23251616
- Expression and function of GSTA1 in lung cancer cells. | Pan, XD., et al. 2014. Asian Pac J Cancer Prev. 15: 8631-5. PMID: 25374180
- The GSTA1 polymorphism and cyclophosphamide therapy outcomes in lupus nephritis patients. | Wang, HN., et al. 2015. Clin Immunol. 160: 342-8. PMID: 26222310
- GSTA1 Expression Is Correlated With Aldosterone Level in KCNJ5-Mutated Adrenal Aldosterone-Producing Adenoma. | Li, X., et al. 2018. J Clin Endocrinol Metab. 103: 813-823. PMID: 29165597
- The analysis of GSTA1 promoter genetic and functional diversity of human populations. | Mlakar, V., et al. 2021. Sci Rep. 11: 5038. PMID: 33658540
- Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. | Zhang, Y., et al. 2021. J Appl Toxicol. 41: 2011-2020. PMID: 33959992
- Effect of GSTA1 Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians. | Nguyen, AH., et al. 2022. Pharmaceutics. 14: PMID: 35214132
- GSTA1/CTNNB1 axis facilitates sorafenib resistance via suppressing ferroptosis in hepatocellular carcinoma. | Ma, S., et al. 2024. Pharmacol Res. 210: 107490. PMID: 39510148
- Computational insights into the inhibitory effects of PFAS 14 on colorectal cancer targeting GSTA1 through competitive binding. | Li, J., et al. 2025. Ecotoxicol Environ Saf. 292: 117925. PMID: 40037076
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSTA1 Antibody (286CT8.1.5) | sc-517334 | 100 µg/ml | $316.00 |