Date published: 2025-10-23

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Gsta1 Inhibitors

The chemical class of GSTA1 inhibitors is characterized by a diverse array of compounds that primarily function by modulating glutathione levels or affecting glutathione-related pathways, thereby indirectly influencing GSTA1 activity. These compounds do not target GSTA1 directly but exert their effects through alterations in the cellular redox state and glutathione metabolism, crucial for GSTA1 function. Key mechanisms by which these inhibitors operate include the depletion of glutathione levels and the modulation of glutathione metabolism. Compounds such as ethacrynic acid, cinnamaldehyde, diethyl maleate, and sulfasalazine interact with glutathione, either by reacting with it or by binding to it, thus reducing its availability for conjugation reactions mediated by GSTA1. This reduction in available glutathione indirectly inhibits GSTA1 activity, as the enzyme requires glutathione to function effectively. For instance, ethacrynic acid reacts with glutathione, leading to its depletion, while cinnamaldehyde binds to glutathione, reducing its free levels in the cell.

Other compounds like β-naphthoflavone, sulforaphane, and ellagic acid influence GSTA1 activity by inducing other enzymes involved in glutathione metabolism or phase II detoxification. This induction can lead to competition for substrates or cofactors, indirectly affecting GSTA1 function. Additionally, natural compounds such as curcumin, capsaicin, chrysin, quercetin, and resveratrol modulate antioxidant pathways and glutathione conjugation processes. These compounds can alter the redox state of the cell and influence the overall dynamics of glutathione metabolism, impacting GSTA1 indirectly.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ethacrynic acid

58-54-8sc-257424
sc-257424A
1 g
5 g
$49.00
$229.00
5
(1)

Reacts with glutathione, depleting its availability for GSTA1.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

Binds to glutathione, reducing its availability for GSTA1 conjugation.

β-Naphthoflavone

6051-87-2sc-205597
sc-205597A
sc-205597B
sc-205597C
1 g
5 g
25 g
100 g
$32.00
$126.00
$587.00
$1615.00
2
(0)

Induces other GST enzymes, possibly leading to reduced GSTA1 activity due to substrate competition.

Diethylmaleate

141-05-9sc-202577
5 g
$26.00
4
(1)

Depletes glutathione levels, indirectly inhibiting GSTA1 function.

Sulfasalazine

599-79-1sc-204312
sc-204312A
sc-204312B
sc-204312C
1 g
2.5 g
5 g
10 g
$60.00
$75.00
$125.00
$205.00
8
(1)

Its metabolites can bind to glutathione, reducing its availability for GSTA1.

Ellagic Acid, Dihydrate

476-66-4sc-202598
sc-202598A
sc-202598B
sc-202598C
500 mg
5 g
25 g
100 g
$57.00
$93.00
$240.00
$713.00
8
(1)

Alters glutathione levels, indirectly impacting GSTA1 function.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$94.00
$173.00
$255.00
$423.00
26
(1)

Influences glutathione metabolism, potentially affecting GSTA1.

Chrysin

480-40-0sc-204686
1 g
$37.00
13
(1)

Affects glutathione levels, indirectly modulating GSTA1 activity.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Modulates antioxidant pathways, potentially affecting GSTA1 function.