GSDML Antibody (3D8): sc-101239

GSDML Antibody (3D8) is a mouse monoclonal IgG2b kappa light chain antibody that detects GSDML protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GSDML antibody (3D8) is available as a non-conjugated format. GSDML, also known as gasdermin-like, GSDMB, PP4052, or PRO2521, is a member of the gasdermin-domain containing (GSDMDC) family of proteins, which play crucial roles in various cellular processes such as cell-cycle regulation, extracellular matrix production, differentiation, and apoptosis. GSDML is involved in regulating inflammatory responses and potentially influences cancer progression, showing expression in both cancerous and non-cancerous tissues. GSDML primarily localizes in the cytoplasm and secretory vesicles, influencing cellular signaling pathways. GSDML gene emerged from a duplication event of the GSDM1 gene, which encodes gasdermin, with multiple isoforms contributing to diverse functional roles in health and disease.

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GSDML Antibody (3D8) References:

1. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon.  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 24: 757-63. PMID: 15010812
2. Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 765-70. PMID: 15289881
3. Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells.  |  Sin, HS., et al. 2006. Arch Virol. 151: 1985-94. PMID: 16625320
4. [Progress of researches on gene function of GSDMDC family].  |  Sun, Q., et al. 2006. Yi Chuan. 28: 596-600. PMID: 16735241
5. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.  |  Tamura, M., et al. 2007. Genomics. 89: 618-29. PMID: 17350798
6. Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma.  |  Nguyen, ST., et al. 2007. Cancer Sci. 98: 740-6. PMID: 17391312
7. Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues.  |  Carl-McGrath, S., et al. 2008. Pathology. 40: 13-24. PMID: 18038310