GS2 Antibody (E-8): sc-393988

GS2 Antibody (E-8) is a mouse monoclonal IgG3 kappa light chain antibody that detects GS2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GS2 antibody (E-8) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. GS2, also known as DXS1283E or patatin-like phospholipase domain containing 4 (PNPLA4), plays a crucial role in lipid metabolism, particularly in the regulation of lipolysis in adipose tissue. GS2 is expressed in various tissues, including the brain, heart, lung, muscle, placenta, liver, spleen, pancreas, and kidney, with particularly high expression levels in adipose tissue. GS2 presence is significant because GS2 contributes to the breakdown of triglycerides, which is essential for maintaining energy homeostasis in the body. Additionally, GS2 interacts with other members of the Adiponutrin family, such as adipocyte triglyceride lipase (ATGL) and GS2-like (patatin-like phospholipase domain containing 5), to modulate lipid storage and mobilization. The coordinated action of these proteins is vital for metabolic health, and dysregulation can lead to conditions such as obesity and insulin resistance. GS2 (E-8) antibody is an invaluable resource for scientists investigating lipid metabolism and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GS2 Antibody (E-8) References:

1. Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage.  |  Baulande, S., et al. 2001. J Biol Chem. 276: 33336-44. PMID: 11431482
2. Adiponutrin: A new gene regulated by energy balance in human adipose tissue.  |  Liu, YM., et al. 2004. J Clin Endocrinol Metab. 89: 2684-9. PMID: 15181042
3. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.  |  Jenkins, CM., et al. 2004. J Biol Chem. 279: 48968-75. PMID: 15364929
4. Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase.  |  Gao, J. and Simon, M. 2005. J Invest Dermatol. 124: 1259-66. PMID: 15955102
5. Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.  |  Lake, AC., et al. 2005. J Lipid Res. 46: 2477-87. PMID: 16150821
6. Characterization of the human patatin-like phospholipase family.  |  Wilson, PA., et al. 2006. J Lipid Res. 47: 1940-9. PMID: 16799181
7. Isolation of a new gene GS2 (DXS1283E) from a CpG island between STS and KAL1 on Xp22.3.  |  Lee, WC., et al. 1994. Genomics. 22: 372-6. PMID: 7806223

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GS2 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GS2 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GS2 Antibody (E-8) Specifications

Alternate Product Name: GS2

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 90-121

Epitope Target: GS2

Epitope Species: human

Product Reactivity/Detection: GS2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GS2 Antibody (E-8): P: Blocking Peptide