GRP Antibody (E-11): sc-271045

GRP Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects gastrin-releasing peptide (GRP) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-GRP antibody (E-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. GRP plays a crucial role in stimulating the release of gastrin and other gastrointestinal hormones, which are essential for digestive processes. GRP acts as an autocrine growth factor for certain cell types, influencing cell proliferation and survival. GRP′s involvement in promoting lung tumorigenesis in model systems highlights significance in cancer research, while regulation by retinoic acid suggests a complex interplay with other signaling pathways. GRP is implicated in hypothalamic regulation of pituitary hormone secretion, making GRP a key player in neuroendocrine functions. Mapping to human chromosome 18q21, GRP′s diverse roles in both gastrointestinal and neuroendocrine systems underscore importance in health and disease, making GRP monoclonal antibody (E-11) an invaluable tool for researchers studying these critical biological processes.

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GRP Antibody (E-11) References:

1. Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone.  |  Song, G., et al. 2008. Biol Reprod. 79: 376-86. PMID: 18448839
2. Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.  |  Ischia, J., et al. 2014. BJU Int. 113 Suppl 2: 40-7. PMID: 24894852
3. Human gastrin-releasing peptide gene maps to chromosome band 18q21.  |  Lebacq-Verheyden, AM., et al. 1987. Somat Cell Mol Genet. 13: 81-6. PMID: 3027901
4. Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis.  |  Choi, Y., et al. 2020. Cells. 10: PMID: 33396360
5. GRP/GRPR enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway.  |  Li, H., et al. 2024. Hepatology. 79: 392-408. PMID: 37409771
6. Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue.  |  Gregory, RA., et al. 1969. Gut. 10: 603-8. PMID: 5822140
7. Molecular cloning and sequencing of the murine gastrin gene.  |  Koh, TJ. and Wang, TC. 1995. Biochem Biophys Res Commun. 216: 34-41. PMID: 7488110
8. Multicolor FISH mapping with Alu-PCR-amplified YAC clone DNA determines the order of markers in the BRCA1 region on chromosome 17q12-q21.  |  Flejter, WL., et al. 1993. Genomics. 17: 624-31. PMID: 8244379
9. Physiology of isolated gastric endocrine cells.  |  Sachs, G., et al. 1997. Annu Rev Physiol. 59: 243-56. PMID: 9074763
10. Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.  |  Ravi, RK., et al. 1998. Oncol Rep. 5: 497-501. PMID: 9468588
11. Growth stimulation of normal melanocytes and nevocellular nevus cells by gastrin releasing peptide (GRP).  |  Terashi, H., et al. 1998. J Dermatol Sci. 17: 93-100. PMID: 9673890
12. Role of corticotropin-releasing hormone in gastrin-releasing peptide-mediated regulation of corticotropin and corticosterone secretion in male rats.  |  Garrido, MM., et al. 1998. Neuroendocrinology. 68: 116-22. PMID: 9705578

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GRP Antibody (E-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-GRP Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GRP Antibody (E-11) Specifications

Alternate Product Name: GRP

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-148

Epitope Target: GRP

Epitope Species: human

Product Reactivity/Detection: GRP and neuromedin C active peptides

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for GRP Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin