group IVD sPLA2 Antibody (H-6): sc-398758
- group IVD sPLA2 Antibody (H-6) is a mouse monoclonal IgG3 κ group IVD sPLA2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 805-828 within a C-terminal cytoplasmic domain of group IVD sPLA2 of mouse origin
- recommended for detection of group IVD sPLA2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for group IVD sPLA2 Antibody (H-6) for WB applications. These reagents are now offered in bundles with group IVD sPLA2 Antibody (H-6) (see ordering information below).
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Group IVD sPLA2 Antibody (H-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects group IVD sPLA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-group IVD sPLA2 antibody (H-6) is available as the non-conjugated format. Group IVD sPLA2, also known as phospholipase A2 group IVD or cPLA2-delta, is a calcium-dependent enzyme consisting of 818 amino acids and features a phospholipase A2c domain and a C2 domain, existing in two alternatively spliced isoforms. This enzyme plays a crucial role in lipid metabolism by hydrolyzing the sn-2-acyl ester bond in glycerophospholipids, which leads to the release of fatty acids, including arachidonic acid. Arachidonic acid is a key precursor for the synthesis of various eicosanoids, which are important mediators of inflammation and are involved in numerous physiological processes. The presence of group IVD sPLA2 in inflammatory conditions, such as psoriatic lesions, highlights its potential significance in understanding and targeting inflammatory pathways. Group IVD sPLA2 (H-6) antibody enables researchers to gain valuable insights into the functional roles of this enzyme in both normal physiology and disease states.
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group IVD sPLA2 Antibody (H-6) References:
- Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. | Ishizaki, J., et al. 1999. J Biol Chem. 274: 24973-9. PMID: 10455175
- Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin. | Chiba, H., et al. 2004. J Biol Chem. 279: 12890-7. PMID: 14709560
- A family based study of the genetic association between the PLA2G4D gene and schizophrenia. | Tao, R., et al. 2005. Prostaglandins Leukot Essent Fatty Acids. 73: 419-22. PMID: 16213696
- [Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia]. | Yu, Q., et al. 2008. Zhonghua Liu Xing Bing Xue Za Zhi. 29: 173-6. PMID: 18686860
- HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. | Mavoungou, E., et al. 1997. J Acquir Immune Defic Syndr Hum Retrovirol. 16: 1-9. PMID: 9377118
- Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. | Schröder, HC., et al. 1998. Neurotoxicology. 19: 683-8. PMID: 9745929
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
group IVD sPLA2 Antibody (H-6) | sc-398758 | 200 µg/ml | $322.00 | |||
group IVD sPLA2 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-524474 | 200 µg Ab, 40 µg BP | $361.00 | |||
group IVD sPLA2 Antibody (H-6): m-IgG3 BP-HRP Bundle | sc-550366 | 200 µg Ab; 40 µg BP | $361.00 | |||
group IVD sPLA2 (H-6) Neutralizing Peptide | sc-398758 P | 100 µg/0.5 ml | $69.00 |