GRIP-1 Antibody (29): sc-136244
- GRIP-1 Antibody (29) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 959-1067 of GRIP-1 of human origin
- recommended for detection of GRIP-1 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GRIP-1 Antibody (29). This work is in progress.
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GRIP-1 Antibody (29) is a mouse monoclonal IgG1 antibody that detects GRIP-1 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GRIP-1, also known as nuclear receptor coactivator 2 (NCoA-2 or Tif2), plays a crucial role in gene expression regulation by acting as a transcriptional coactivator for steroid hormone receptors. GRIP-1 is primarily located in the nucleus, where GRIP-1 interacts with various nuclear receptors to enhance transcriptional activity. GRIP-1′s nuclear localization enables modulation of genes involved in critical biological processes, including metabolism, development, and cell differentiation. GRIP-1 interacts with other proteins such as p300 and CBP, which are essential for transcriptional activation of numerous target genes. GRIP-1′s ability to form complexes with these coactivators underscores GRIP-1′s significance in transcriptional regulation of hormone-responsive genes, making GRIP-1 a vital component in understanding hormonal signaling pathways and their implications in diseases such as cancer.
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GRIP-1 Antibody (29) References:
- Association of GRIP1 with a GABA(A) receptor associated protein suggests a role for GRIP1 at inhibitory synapses. | Kittler, JT., et al. 2004. Biochem Pharmacol. 68: 1649-54. PMID: 15451408
- GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. | Hoogenraad, CC., et al. 2005. Nat Neurosci. 8: 906-15. PMID: 15965473
- The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. | Reily, MM., et al. 2006. EMBO J. 25: 108-17. PMID: 16362036
- GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. | Mao, L., et al. 2010. Proc Natl Acad Sci U S A. 107: 19038-43. PMID: 20956289
- The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. | Geiger, JC., et al. 2014. Dev Cell. 28: 381-93. PMID: 24576423
- Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade. | Gainey, MA., et al. 2015. Proc Natl Acad Sci U S A. 112: E3590-9. PMID: 26109571
- GRIP1 is required for homeostatic regulation of AMPAR trafficking. | Tan, HL., et al. 2015. Proc Natl Acad Sci U S A. 112: 10026-31. PMID: 26216979
- Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. | Rollins, DA., et al. 2017. Nat Commun. 8: 1739. PMID: 29170386
- GRIP1 regulates synaptic plasticity and learning and memory. | Tan, HL., et al. 2020. Proc Natl Acad Sci U S A. 117: 25085-25091. PMID: 32948689
- Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy. | Mimouna, S., et al. 2021. J Exp Med. 218: PMID: 33045064
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRIP-1 Antibody (29) | sc-136244 | 50 µg/0.5 ml | $322.00 |