GRIFIN Antibody (50): sc-136350
- GRIFIN Antibody (50) is a mouse monoclonal IgG1 κ GRIFIN antibody provided at 200 µg/ml
- raised against amino acids 31-144 of GRIFIN of rat origin
- recommended for detection of GRIFIN of mouse and rat origin by WB and IP
- available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRIFIN Antibody (50) for WB applications. These reagents are now offered in bundles with GRIFIN Antibody (50) (see ordering information below).
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GRIFIN Antibody (50) is a mouse monoclonal IgG1 kappa light chain antibody that detects GRIFIN protein of mouse and rat origin by western blotting (WB) and immunoprecipitation (IP). Anti-GRIFIN antibody (50) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). GRIFIN protein, also known as galectin-related inter-fiber protein, is a unique 144 amino acid protein that forms a homodimer and features a galectin domain, which is crucial for its function in the lens of the eye. As a highly abundant soluble lens protein, GRIFIN serves as a binding partner for α-crystallin, contributing to the maintenance of lens transparency and refractive properties. The gene encoding GRIFIN is located on mouse chromosome 5 G2, while its human counterpart maps to chromosome 7, a region associated with various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome. GRIFIN′s interaction with other lens proteins is vital for the structural integrity and function of the lens, highlighting GRIFIN′s importance in ocular health and potential implications in lens-related pathologies.
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GRIFIN Antibody (50) References:
- Long-term audiological feature in Pendred syndrome caused by PDS mutation. | Iwasaki, S., et al. 2001. Arch Otolaryngol Head Neck Surg. 127: 705-8. PMID: 11405873
- Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization. | Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
- Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more. | Reiner, O., et al. 2006. Neuromolecular Med. 8: 547-65. PMID: 17028375
- Therapy-related leukemia and myelodysplasia: susceptibility and incidence. | Leone, G., et al. 2007. Haematologica. 92: 1389-98. PMID: 17768113
- Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens. | Barton, KA., et al. 2009. Biochemistry. 48: 3956-66. PMID: 19296714
- Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta. | Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
- Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci. | Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444
- GRIFIN, a novel lens-specific protein related to the galectin family. | Ogden, AT., et al. 1998. J Biol Chem. 273: 28889-96. PMID: 9786891
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRIFIN Antibody (50) | sc-136350 | 200 µg/ml | $316.00 | |||
GRIFIN Antibody (50): m-IgG Fc BP-HRP Bundle | sc-528816 | 200 µg Ab; 10 µg BP | $354.00 | |||
GRIFIN Antibody (50): m-IgGκ BP-HRP Bundle | sc-521360 | 200 µg Ab, 40 µg BP | $354.00 | |||
GRIFIN Antibody (50): m-IgG1 BP-HRP Bundle | sc-543147 | 200 µg Ab; 20 µg BP | $354.00 | |||
GRIFIN Antibody (50) AC | sc-136350 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GRIFIN Antibody (50) HRP | sc-136350 HRP | 200 µg/ml | $316.00 |