GRIFIN Antibody (50): sc-136350

GRIFIN Antibody (50) is a mouse monoclonal IgG1 kappa light chain antibody that detects GRIFIN protein of mouse and rat origin by western blotting (WB) and immunoprecipitation (IP). Anti-GRIFIN antibody (50) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). GRIFIN protein, also known as galectin-related inter-fiber protein, is a unique 144 amino acid protein that forms a homodimer and features a galectin domain, which is crucial for its function in the lens of the eye. As a highly abundant soluble lens protein, GRIFIN serves as a binding partner for α-crystallin, contributing to the maintenance of lens transparency and refractive properties. The gene encoding GRIFIN is located on mouse chromosome 5 G2, while its human counterpart maps to chromosome 7, a region associated with various genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome. GRIFIN′s interaction with other lens proteins is vital for the structural integrity and function of the lens, highlighting GRIFIN′s importance in ocular health and potential implications in lens-related pathologies.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

GRIFIN Antibody (50) References:

1. Long-term audiological feature in Pendred syndrome caused by PDS mutation.  |  Iwasaki, S., et al. 2001. Arch Otolaryngol Head Neck Surg. 127: 705-8. PMID: 11405873
2. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
3. Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.  |  Reiner, O., et al. 2006. Neuromolecular Med. 8: 547-65. PMID: 17028375
4. Therapy-related leukemia and myelodysplasia: susceptibility and incidence.  |  Leone, G., et al. 2007. Haematologica. 92: 1389-98. PMID: 17768113
5. Interactions between small heat shock protein alpha-crystallin and galectin-related interfiber protein (GRIFIN) in the ocular lens.  |  Barton, KA., et al. 2009. Biochemistry. 48: 3956-66. PMID: 19296714
6. Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.  |  Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
7. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444
8. GRIFIN, a novel lens-specific protein related to the galectin family.  |  Ogden, AT., et al. 1998. J Biol Chem. 273: 28889-96. PMID: 9786891

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GRIFIN Antibody (50) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GRIFIN Antibody (50) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GRIFIN Antibody (50) Specifications

Alternate Product Name: GRIFIN

Product Clone Name: 50

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 31-144

Epitope Target: GRIFIN

Epitope Species: rat

Product Reactivity/Detection: GRIFIN

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GRIFIN Antibody (50): AC: Agarose, HRP: Horseradish Peroxidase