GRF-1 Antibody (2389D3a): sc-81094
- GRF-1 Antibody (2389D3a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of GRF-1 of human origin
- recommended for detection of GRF-1 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GRF-1 Antibody (2389D3a). This work is in progress.
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SEE ALSO...
GRF-1 Antibody (2389D3a) is a mouse monoclonal IgG1 antibody that detects GRF-1 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. GRF-1, also known as glucocorticoid receptor DNA-binding factor 1 or p190RhoGAP, is a crucial transcriptional regulator that binds to the promoter region of the glucocorticoid receptor gene, thereby repressing its expression. This repression is significant as it down-regulates Rho signaling, which is essential for mediating actin cytoskeletal rearrangements and regulating cell cycle events. GRF-1′s function is particularly important in the context of oligodendrocyte differentiation, a process that is disrupted in malignant glioma tumors, suggesting GRF-1 may act as a tumor suppressor. Additionally, GRF-1 is subject to post-translational modifications, including ubiquitination, which affects stability and activity by regulating the degradation of its GTP binding region. GRF-1 expression is also modulated by glucocorticoids, and exists in two isoforms due to alternative splicing, highlighting the complexity of regulatory mechanisms and potential implications in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRF-1 Antibody (2389D3a) | sc-81094 | 100 µg/ml | $339.00 |