Grancalcin Antibody (H-7): sc-374003
- Grancalcin Antibody (H-7) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 21-55 near the N-terminus of Grancalcin of human origin
- recommended for detection of Grancalcin of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Grancalcin Antibody (H-7) for WB applications. This reagent is now offered in a bundle with Grancalcin Antibody (H-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Grancalcin Antibody (H-7) is a mouse monoclonal IgG3 antibody that detects Grancalcin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Grancalcin is a calcium-binding protein predominantly found in human neutrophils and is a member of the penta EF-hand (PEF) subfamily of EF-hand proteins, which includes calpain, sorcin, peflin, and ALG-2. Grancalcin undergoes significant conformational changes upon calcium binding, exposing hydrophobic amino acid residues that facilitate interaction with hydrophobic surfaces. Grancalcin forms a homodimer through the association of unpaired EF5 hands, enhancing stability and functional capacity. Grancalcin′s interaction with L-plastin, a protein recognized for actin bundling activity, suggests a vital role in regulating neutrophil adhesion, essential for immune response and inflammation. Grancalcin is primarily associated with cells derived from bone marrow, being particularly abundant in neutrophils and monocytes, while only trace amounts are found in lymphocytes, highlighting significance in innate immunity and cellular signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Grancalcin Antibody (H-7) | sc-374003 | 200 µg/ml | $322.00 | |||
Grancalcin Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-552021 | 200 µg Ab; 40 µg BP | $361.00 | |||
Grancalcin (H-7) Neutralizing Peptide | sc-374003 P | 100 µg/0.5 ml | $69.00 |