GPR84 Antibody (1D9): sc-293447

GPR84 Antibody (1D9) is a mouse monoclonal IgG1 kappa light chain antibody that detects GPR84 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GPR84 antibody (1D9) is available as the non-conjugated isotype antibody. GPR84, a member of the G protein-coupled receptor (GPCR) family, plays a crucial role in immune responses, particularly in activated T cells where GPR84 regulates early interleukin-4 (IL-4) gene expression, a key cytokine involved in the differentiation of T helper cells. The importance of GPR84 extends beyond immune regulation; GPR84 is also implicated in various physiological processes and pathological conditions, including inflammation and metabolic disorders. This orphan receptor is expressed in a wide range of tissues, including the brain, heart, muscle, colon, and peripheral blood leukocytes, highlighting GPR84′s potential as a therapeutic target. Understanding the function of GPR84 and its interactions within the immune system can provide insights into novel treatment strategies for diseases characterized by immune dysregulation.

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GPR84 Antibody (1D9) References:

1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.  |  Wittenberger, T., et al. 2001. J Mol Biol. 307: 799-813. PMID: 11273702
2. Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes.  |  Yousefi, S., et al. 2001. J Leukoc Biol. 69: 1045-52. PMID: 11404393
3. Sequence alignment of the G-protein coupled receptor superfamily.  |  Probst, WC., et al. 1992. DNA Cell Biol. 11: 1-20. PMID: 1310857
4. The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking.  |  Venkataraman, C. and Kuo, F. 2005. Immunol Lett. 101: 144-53. PMID: 15993493
5. Structure and function of G protein coupled receptors.  |  Lameh, J., et al. 1990. Pharm Res. 7: 1213-21. PMID: 1965663
6. Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84.  |  Nikaido, Y., et al. 2015. J Biochem. 157: 311-20. PMID: 25425658
7. Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.  |  Mahmud, ZA., et al. 2017. Sci Rep. 7: 17953. PMID: 29263400
8. IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes.  |  Zaibi, MS., et al. 2018. Cytokine. 110: 189-193. PMID: 29775920
9. The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.  |  Mårtensson, J., et al. 2021. J Innate Immun. 13: 242-256. PMID: 33789297
10. GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects.  |  Timmis, H., et al. 2021. Clin Pharmacol Drug Dev. 10: 994-1006. PMID: 33960725
11. Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells.  |  Peiris, M., et al. 2022. Gut. 71: 928-937. PMID: 34083384
12. Function and regulation of GPR84 in human neutrophils.  |  Forsman, H., et al. 2024. Br J Pharmacol. 181: 1536-1549. PMID: 36869866

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GPR84 Antibody (1D9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GPR84 Antibody (1D9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GPR84 Antibody (1D9) Specifications

Alternate Product Name: GPR84

Product Clone Name: 1D9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 208-316

Epitope Target: GPR84

Epitope Species: human

Product Reactivity/Detection: GPR84

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GPR84 Antibody (1D9): N/A