GPIHBP1 Antibody (F-4): sc-376598

GPIHBP1 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects GPIHBP1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPIHBP1 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GPIHBP1, or glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1, plays a crucial role in lipid metabolism by facilitating chylomicron transport from intestines to other tissues. Located in capillary endothelial cells, GPIHBP1 serves as a platform for lipoprotein lipase-mediated hydrolysis of triglycerides in chylomicrons, primarily in heart, skeletal muscle, and adipose tissue. This interaction ensures efficient lipid processing, preventing accumulation and associated metabolic disorders. GPIHBP1 consists of 184 amino acids and functions as a single-pass membrane protein influenced by dietary factors and peroxisome proliferator-activated receptor gamma (PPARγ). Mutations in GPIHBP1 are associated with chylomicronemia syndrome, a rare genetic disorder characterized by lipoprotein lipase deficiency, leading to symptoms such as enlarged liver and spleen, pancreatitis, and fatty deposits in various tissues, including skin and retina.

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GPIHBP1 Antibody (F-4) References:

1. Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution.  |  Gin, P., et al. 2007. Biochim Biophys Acta. 1771: 1464-8. PMID: 17997385
2. Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models.  |  Véniant, MM., et al. 2008. Curr Drug Targets. 9: 174-89. PMID: 18336235
3. Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase.  |  Beigneux, AP., et al. 2008. J Lipid Res. 49: 1312-21. PMID: 18340083
4. The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons.  |  Gin, P., et al. 2008. J Biol Chem. 283: 29554-62. PMID: 18713736
5. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma.  |  Davies, BS., et al. 2008. Mol Endocrinol. 22: 2496-504. PMID: 18787041
6. GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins.  |  Beigneux, AP., et al. 2009. J Lipid Res. 50 Suppl: S57-62. PMID: 18854402
7. GPIHBP1 and lipolysis: an update.  |  Beigneux, AP., et al. 2009. Curr Opin Lipidol. 20: 211-6. PMID: 19369870
8. Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia.  |  Olivecrona, G., et al. 2010. J Lipid Res. 51: 1535-45. PMID: 20026666
9. Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects.  |  Franssen, R., et al. 2010. Circ Cardiovasc Genet. 3: 169-78. PMID: 20124439
10. GPIHBP1, an endothelial cell transporter for lipoprotein lipase.  |  Young, SG., et al. 2011. J Lipid Res. 52: 1869-84. PMID: 21844202
11. GPIHBP1 and Plasma Triglyceride Metabolism.  |  Fong, LG., et al. 2016. Trends Endocrinol Metab. 27: 455-469. PMID: 27185325
12. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.  |  Beigneux, AP., et al. 2017. N Engl J Med. 376: 1647-1658. PMID: 28402248

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GPIHBP1 Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GPIHBP1 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GPIHBP1 Antibody (F-4) Specifications

Alternate Product Name: GPIHBP1

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 123-161

Epitope Target: GPIHBP1

Epitope Species: human

Product Reactivity/Detection: GPIHBP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GPIHBP1 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin